98834-08-3

Basic information

• Product Name: MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE
• Synonyms: AKOS BBS-00005890;4-(PIPERAZIN-1-YLCARBONYL)MORPHOLINE;IFLAB-BB F1757-0249;PIPERAZINO-CARBOXYLIC ACID-MORPHOLIDE;MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE;MORPHOLINE-4-YL-PIPERAZINE-1-YL-METHANONE;MORPHOLINEPIPERAZINEMETHANONE;TIMTEC-BB SBB003554
• CAS NO: 98834-08-3
• Molecular Formula: C₉H₁₇N₃O₂
• Molecular Weight: 199.25
• Mol File: 98834-08-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 331.1°Cat760mmHg
• Flash Point: 154.1°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0.000159mmHg at 25°C
• Refractive Index: 1.52
• PKA: 8.48±0.10(Predicted)
• CAS DataBase Reference: MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE(98834-08-3)
• EPA Substance Registry System: MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE(98834-08-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 98834-08-3(Hazardous Substances Data)

Usage

General Description

MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE is a chemical compound with the molecular formula C11H20N4O. It is a derivative of piperazine, a heterocyclic organic compound, and contains a morpholine ring, which is a saturated heterocyclic organic compound containing both nitrogen and oxygen atoms. MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and medications. It has shown potential as an antipsychotic and antidepressant agent, and its unique structure makes it a versatile molecule for drug development. MORPHOLIN-4-YL-PIPERAZIN-1-YL-METHANONE is a promising chemical compound with various potential applications in the field of medicine and pharmacology.

InChI:InChI=1/C9H17N3O2/c13-9(11-3-1-10-2-4-11)12-5-7-14-8-6-12/h10H,1-8H2

Upstream product

• 59878-28-3 tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylate 
• 110-91-8 morpholine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 15159-40-7 4-morpholinocarbonyl chloride 
• 163587-60-8 4-(4-morpholinylcarbonyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester 

Downstream Products

• 700856-05-9 (4-(4-chlorophenyl)piperazin-1-yl)(morpholino)methanone 
• 1548116-20-6 N-methyl-4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzamide 
• 1548116-25-1 N,N-dimethyl-4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzamide 
• 1353553-19-1 (4-(4-aminophenyl)piperazin-1-yl)(morpholino)methanone 
• 1548116-39-7 N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)acetamide 
• 1548116-45-5 N-(4-(4-(morpholine-4-carbonyl)piperazin-1-yl)phenyl)methanesulfonamide 
• 1548115-92-9 (4-(4-iodophenyl)piperazin-1-yl)(morpholino)methanone 
• 1548118-12-2 morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone 
• 1548115-75-8 (4-(4-ethynylphenyl)piperazin-1-yl)(morpholino)methanone 
• 1548116-09-1 4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzoic acid 
• 1548119-96-5 C₁₆H₂₀ClN₃O₃ 
• 1548116-15-9 4-(4-(morpholine-4-carbonyl)piperazin-1-yl)benzamide 
• 349118-82-7 Morpholino(4-phenylpiperazin-1-yl)methanone 
• 1548115-18-9 morpholino(4-(o-tolyl)piperazin-1-yl)methanone 

Relevant articles and documents

Piperazine ureido derivative, preparation method thereof and application of piperazine ureido derivative in medicine

The invention relates to piperazine ureido derivatives, a preparation method thereof and an application of the piperazine ureido derivatives in medicine. In particular, the invention relates to piperazine ureido derivatives as shown in a general formula (I), a preparation method thereof, pharmaceutical compositions containing the derivatives, and uses thereof as capsid protein inhibitors, especially in prevention and/or treatment of hepatitis B, influenza, herpes, AIDS and other diseases. Wherein the definition of each group in the general formula (I) is the same as that in the specification.

Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)

Inhibitors of the aldo-keto reductase enzyme AKR1C3 are of interest as potential drugs for leukemia and hormone-related cancers A series of non-carboxylate morpholino(phenylpiperazin-1-yl)methanones were prepared by palladium-catalysed coupling of substit