98841-60-2Relevant academic research and scientific papers
Deoxygenative C-S Bond Coupling with Sulfinates via Nickel/Photoredox Dual Catalysis
Deng, Guo-Jun,Huang, Huawen,Mao, Guojiang,Zhao, Feng,Zhong, Shuai,Zhou, Zhiwei
supporting information, p. 1865 - 1870 (2022/03/16)
The C-S bond formation from aryl halides and thiols has been well established under various catalytic systems. In this work, user-friendly sulfinates have been exploited as an efficient sulfenylating reagent in the C-S couplings through visible-light-induced photo/nickel dual catalysis under base- and external reductant-free conditions. A large number of aryl sulfide products were accessed with high selectivity and high tolerance of various functionalities.
Discovery of Novel Tricyclic Thiazepine Derivatives as Anti-Drug-Resistant Cancer Agents by Combining Diversity-Oriented Synthesis and Converging Screening Approach
Xiang, Jinbao,Zhang, Zhuoqi,Mu, Yan,Xu, Xianxiu,Guo, Sigen,Liu, Yongjin,Russo, Daniel P.,Zhu, Hao,Yan, Bing,Bai, Xu
supporting information, p. 230 - 235 (2016/06/01)
An efficient discovery strategy by combining diversity-oriented synthesis and converging cellular screening is described. By a three-round screening process, we identified novel tricyclic pyrido[2,3-b][1,4]benzothiazepines showing potent inhibitory activity against paclitaxel-resistant cell line H460TaxR (EC50 50 > 100 μM against normal human fibroblasts). The most active hits also exhibited drug-like properties suitable for further preclinical research. This redeployment of antidepressing compounds for anticancer applications provides promising future prospects for treating drug-resistant tumors with fewer side effects.
Heteroaromatic thioether-boronic acid cross-coupling under neutral reaction conditions.
Liebeskind, Lanny S,Srogl, Jiri
, p. 979 - 981 (2007/10/03)
[reaction: see text] Pi-deficient heteroaromatic thioethers undergo efficient palladium-catalyzed cross-coupling with boronic acids mediated by copper(I) thiophene-2-carboxylate.
Nucleophilic substitutions at the pyridine ring. Conformational preference of the products and kinetics of the reactions of 2-chloro-3-nitro- and 2-chloro-5-nitro-pyridines with arenethiolates
Hamed, Ezzat A.,El-Bardan, Ali A.,Saad, Esmat F.,Gohar, Gamal A.,Hassan, Ghada M.
, p. 2415 - 2421 (2007/10/03)
The reactions of 2-chloro-3-nitropyridine 1 and 2-chloro-5-nitropyridine 2 with arenethiolates 3a-i result in arylthio-dechlorination to give 2-arylthio-3-nitropyridines 4a-i and 2-arylthio-5-nitropyridines 5a-i. A 1H NMR study and AM1 calculat
