98889-64-6

Upstream product

• 97562-24-8 allyl 2-deoxy-4,6-O-isopropylidene-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside 
• 87357-67-3 (R)-3-benzyloxytetradecanoic acid 

Downstream Products

• 117475-07-7 (R)-3-Benzyloxy-tetradecanoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-(diphenoxy-phosphoryloxy)-3-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2,2,2-trichloro-ethoxycarbonyloxymethyl)-tetrahydro-pyran-4-yl ester 
• 117475-08-8 (R)-3-Benzyloxy-tetradecanoic acid (2R,3R,4R,5S,6R)-2-bromo-5-(diphenoxy-phosphoryloxy)-3-(2,2,2-trichloro-ethoxycarbonylamino)-6-(2,2,2-trichloro-ethoxycarbonyloxymethyl)-tetrahydro-pyran-4-yl ester 
• 98870-61-2 (R)-3-Benzyloxy-tetradecanoic acid (4aR,6S,7R,8R,8aS)-6-allyloxy-7-((R)-3-benzyloxy-tetradecanoylamino)-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 98889-63-5 allyl 3-O-<(R)-3-benzyloxytetradecanoyl>-2-<(R)-3-benzyloxytetradecanoylamino>-2-deoxy-α-D-glucopyranoside 
• 149707-77-7 (R)-3-Benzyloxy-tetradecanoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester 

Relevant academic research and scientific papers

Total Synthesis of Escherichia coli Lipid A, the Endotoxically Active Principle of Cell-Surface Lipopolysaccharide

Chemical synthesis are described of polyacylated β(1->6) glucosamine disaccharide 1,4'-bis(phosphate), which corresponds to the proposed structure of E. coli lipid A, and of its dephospho derivatives.The synthetic bisphosphate proved to be identical with

TOTAL SYNTHESIS OF ESCHERICHIA COLI LIPID A

The first total synthesis of E. coli lipid A (1) is described.The synthetic compound was identical with a natural specimen and exhibited the full endotoxic activity.It was thus conclusively proved by this chemical synthesis that lipid A is the active prin