98910-61-3

Upstream product

• 98910-55-5 3'-methoxyphenyl 3-methylbut-2-enoate 
• 4236-32-2 2,2-dimethyl-5-hydroxy-4-keto-benzopyran 
• 74-88-4 methyl iodide 
• 703-23-1 2'-hydroxy-6'-methoxyacetophenone 
• 67-64-1 acetone 
• 150-19-6 O-methylresorcine 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 159151-03-8 Dimethyl-thiocarbamic acid O-(5-methoxy-2,2-dimethyl-4-oxo-chroman-7-yl) ester 
• 159151-11-8 7-Cyanato-5-methoxy-2,2-dimethyl-chroman-4-one 
• 58230-09-4 2,2-Dimethyl-7-hydroxy-5-methoxy-4-chromanone 
• 159151-05-0 Dimethyl-thiocarbamic acid S-(5-methoxy-2,2-dimethyl-4-oxo-chroman-7-yl) ester 
• 159151-28-7 7-Mercapto-5-methoxy-2,2-dimethyl-chroman-4-one 
• 119840-28-7 1-(2-hydroxy-6-methoxyphenyl)-3-methyl-2-buten-1-one 

Relevant academic research and scientific papers

Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use

The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the inventi

An Efficient Synthesis of 6-oxa-spiro[3.4]octan-1-one Derivates Through 3-diazochroman-4-one and Alkene

Spiro[2,2-dimethyl-benzofuran,bicyclo [4.2.0]octane]-7′-one with fused and spirocyclic oxygen-containing rigid skeleton structure is obtained via Wolff rearrangement and cycloaddition with good yields. Then Spiro[2,2-dimethyl-benzofuran,hexahydro-isobenzofuran]-7′-one is synthesized by further Baeyer-Villiger oxidation. These two kinds of products have a special fused and spirocyclic oxygen-containing rigid skeleton structure and are reported by our group. (Figure presented.).

Facile deoxygenation of hydroxylated flavonoids by palladium-catalysed reduction of its triflate derivatives

An efficient procedure to deoxygenate hydroxy substituted flavonoids, isoflavonoids and related compounds via their trifluoromethanesulfonates is presented. Their reduction with formic acid in the presence of a catalytic amount of palladium acetate, triethylamine and 1,3-bis(diphenyl-phosphanyl) propane (dppp) in DMF results in their des-hyaroxy derivatives without affecting other functional groups.

Modification of hydroxybenzopyranoids: Facile deoxygenation of 2,2-dimethyl-7-hydroxy-4-chromanones and a new approach to their novel mercapto analogs

A facile deoxygenation of a systematic series of substituted 2,2-dimethyl-7-hydroxy-4-chromanones via their sulfonate, isourea, and thiocarbamate derivatives is reported. The synthesis of novel 2,2-dimethyl-7-mercapto-4-chromanones has been accomplished b

STUDIES ON THE SYNTHESIS OF PRECOCENES. THE PHOTO-FRIES REARRANGEMENT OF ESTERS OF α,β-UNSATURATED CARBOXYLIC ACIDS AND META-OXYGENATED PHENOLS

The photo-Fries rearrangement of a series of aryl esters of α,β-unsaturated carboxylic acids 1a,b and 2 has been investigated, in order to explore the possibilities of this reaction as a key step in the synthesis of precocenes and related compounds.In all cases, the photolysis in hexane does not lead to any observable transformation, but in the presence of potassium carbonate takes place a migration of the acyl group to the two ortho-positions.Additionally, trans-cis photoisomerization occurs with the trans-butenoate 1b.The resulting o-hydroxyketones 4a, 4b, 4c, 5a, 5b, 5c, and 8 are easily and efficiently cyclized to the corresponding 4-chromanones 6a, 6b, 7a, 7b, and 9.A second photo-rearrangement is observed in the case of 9, although the yield is low, due to deactivation by the carbonyl group.Cyclization of 10 gives rise to the tricyclic dichromanone 11.Compounds 6a and 11 are reduced and subsequently dehydrated by known procedures to afford the active chromenes 3 and 12.