98917-56-7

Upstream product

• 107856-74-6 C₂₆H₅₀O₄ 
• 95991-03-0 allyl 6-O-{2-deoxy-2-trichloroethoxycarbonylamino-3-O-[(R)-3-tetradecanoyloxytetradecanoyl]-4-O-diphenylphosphono-6-O-trichloroethoxycarbonyl-β-D-glucopyranosyl}-2-deoxy-2-[(R)-3-benzyloxytetradecanoylamino]-3-O-[(R)-3-benzyloxytetradecanoyl]-α-D-glucopyranoside 

Downstream Products

• 117539-70-5 C₁₄₄H₂₂₇N₂O₂₉P 
• 96020-48-3 C₁₃₁H₂₀₉N₂O₂₃P 

Relevant academic research and scientific papers

Process for preparing a disaccharide derivative

Disaccharide derivatives represented by the formula (I): STR1 wherein R1 CO-- and R2 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms and having a hydroxyl group at the 3-position thereof; R3 CO-- and R4 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms; and m and n each represents an integer of from 8 to 12, and the salts thereof. The compounds exhibit biological activities equal to or higher than those of natural lipid A. Also, the compounds of this invention are very useful as standard reagent for determination of endotoxin in the samples to be tested.

Total Synthesis of Escherichia coli Lipid A, the Endotoxically Active Principle of Cell-Surface Lipopolysaccharide

Chemical synthesis are described of polyacylated β(1->6) glucosamine disaccharide 1,4'-bis(phosphate), which corresponds to the proposed structure of E. coli lipid A, and of its dephospho derivatives.The synthetic bisphosphate proved to be identical with

TOTAL SYNTHESIS OF ESCHERICHIA COLI LIPID A

The first total synthesis of E. coli lipid A (1) is described.The synthetic compound was identical with a natural specimen and exhibited the full endotoxic activity.It was thus conclusively proved by this chemical synthesis that lipid A is the active prin