98949-98-5Relevant academic research and scientific papers
Brominated trimetrexate analogues as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase
Rosowsky, Andre,Mota, Clara E.,Queener, Sherry F.
, p. 1959 - 1966 (2007/10/03)
Five previously undescribed trimetrexate analogues with bulky 2'-bromo substitution on the phenyl ring were synthesized in order to assess the effect of this structure modification on dihydrofolate reductase inhibition. Condensation of 2-[2-(2-bromo-3,4,5
