98963-12-3

Usage

Uses

Used in Pharmaceutical Research:
5-(Bromomethyl)-3-phenyl-1,3-oxazolidin-2-one is used as a key intermediate in pharmaceutical research for the development of new drugs. Its unique structure allows for the creation of a variety of biologically active molecules, making it a valuable asset in the discovery and synthesis of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 5-(Bromomethyl)-3-phenyl-1,3-oxazolidin-2-one is used as a building block for the synthesis of other organic compounds. Its bromomethyl group and oxazolidinone ring provide a foundation for the construction of complex organic molecules, facilitating the advancement of chemical research and development.
Used in Drug Development:
5-(Bromomethyl)-3-phenyl-1,3-oxazolidin-2-one is employed as a versatile intermediate in the preparation of various biologically active molecules for drug development. Its chemical properties enable the design and synthesis of innovative pharmaceuticals with potential therapeutic applications.
Used in Chemical Research:
In the realm of chemical research, 5-(Bromomethyl)-3-phenyl-1,3-oxazolidin-2-one is used to explore new chemical reactions and mechanisms. Its reactivity and structural features make it an interesting subject for study, contributing to the broader understanding of chemical processes and the development of new synthetic methods.

Upstream product

• 103-71-9 phenyl isocyanate 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 169268-95-5 tert-butyl allyl(phenyl)carbamate 

Downstream Products

• 367925-74-4 5-azidomethyl-3-phenyl-1,3-oxazolidin-2-one 
• 1174338-41-0 5-{[(4-tert-butylbenzyl) (methyl)amino]methyl}-3-phenyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Direct synthesis of oxazolidin-2-ones from tert-butyl allylcarbamate via halo-induced cyclisation

A novel synthetic pathway towards the 2-oxazolidinone derivatives involving the halo-induced cyclisation of tert-butyl allyl(phenyl)carbamate was successfully developed. Various halogenating reagents were evaluated under different reaction conditions for the reaction optimisation. Interestingly, the synthetic route to 2-oxazolidinone derivatives containing one halogen atom in the aliphatic site or two halogen atoms including the extra halogen atom substituted in the aryl group at the para position, were thoroughly established for all chloro-, bromo- and iodo compounds. Either halo-unsubstituted-aryl oxazolidinone or p-halo-substituted-aryl oxazolidinone could be selectively produced by selecting the appropriate choices of halogenated reagents and reaction conditions e.g. reaction time and temperature. Toloxatone, a commercial antidepressant, was successfully synthesized by using this developed method.

3,5-SUBSTITUTED-1,3-OXAZOLIDIN-2-ONE DERIVATIVES

The present invention is directed to 3,5-disubstituted-l,3-oxazolidin~2-one derivatives which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psyc

Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity

C-5-substituted triazole-oxazolidinones were synthesized using a bromide catalyzed cycloaddition between aryl isocyanates and epibromohydrin followed by a three-component Huisgen cycloaddition. The library of compounds was screened for antibacterial activity against Mycobacterium smegmatis ATCC 14468, Bacillus subtilis ATCC 6633, and Enterococcus faecalis ATCC 29212. Notably, the 3-(4-acetyl-phenyl)-5-(1H-1,2,3-triazol-1-yl)methyl)-oxazolidin-2-one (18) showed an MIC of 1 μg/mL against M. smegmatis ATCC 14468, fourfold lower than the MIC measured for isoniazid.

Samarium triiodide catalyzed cycloaddition of epoxides with isocyanates: A facile synthesis of oxazolidinones

Oxazolidinones were synthesized in high yields via cycloaddition of epoxides with isocyanates catalyzed by samarium triiodide.