367925-74-4

Upstream product

• 73018-98-1 3-azidopropane-1,2-diol 
• 103-71-9 phenyl isocyanate 
• 711-85-3 5-(chloromethyl)-3-phenyl-1,3-oxazolidin-2-one 
• 98963-12-3 5-(bromomethyl)-3-phenyloxazolidin-2-one 

Downstream Products

• 121082-84-6 (l)-5-aminomethyl-3-phenyl-2-oxazolidinone 
• 96800-65-6 <3-(4-acetylphenyl)-2-oxo-5-oxazolidinyl>methyl azide 
• 1071789-03-1 3-phenyl-5-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one 
• 1071789-02-0 5-((4-(2-hydroxyethyl)-1H-1,2,3-triazol-1-yl)methyl)-3-phenyloxazolidin-2-one 
• 1071789-04-2 3-phenyl-5-((4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one 
• 1071789-01-9 5-((4-octyl-1H-1,2,3-triazol-1-yl)methyl)-3-phenyloxazolidin-2-one 
• 367925-77-7 5-acetamidomethyl-3-phenyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

An approach to synthesis of 3-Aryl-2-oxazolidinones and in situ 'click' assembly of 1,2,3-triazole oxazolidinones

A facile and efficient addition of isocyanates with epoxides in the presence of MgI2 etherate was reported in good yields. The corresponding 2-oxazolidinone could be easily converted into 1,2,3-triazole-oxazolidinone by click reaction in excell

Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity

C-5-substituted triazole-oxazolidinones were synthesized using a bromide catalyzed cycloaddition between aryl isocyanates and epibromohydrin followed by a three-component Huisgen cycloaddition. The library of compounds was screened for antibacterial activity against Mycobacterium smegmatis ATCC 14468, Bacillus subtilis ATCC 6633, and Enterococcus faecalis ATCC 29212. Notably, the 3-(4-acetyl-phenyl)-5-(1H-1,2,3-triazol-1-yl)methyl)-oxazolidin-2-one (18) showed an MIC of 1 μg/mL against M. smegmatis ATCC 14468, fourfold lower than the MIC measured for isoniazid.

Synthesis of oxazolidinones by a solid-phase/activation cycloelimination (sp/ace) methodology

A versatile method for the solid-phase synthesis of oxazolidinones is described. An appropriate 1,2-diol is attached to immobilized sulfonyl chloride, resulting in the selective activation of one of the alcohol functions. The subsequent reaction of the ot

Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents

Novel aminomethyl oxooxazolidinyl benzene derivatives, including the sulfides, sulfoxides, sulfones and sulfonamides, such as (l)-N-[3-[4-(methylsulfinyl)phenyl]-2-oxooxazolidin-5-ylmethyl]acetamide, possess useful antibacterial activity.