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Usage

Uses

Used in Pharmaceutical Research:
4,4'-dihydroxy-N,3'-biacetanilide is used as a reagent in pharmaceutical research for investigating mechanisms related to liver and kidney damage caused by acetaminophen. Its study can provide insights into the side effects and toxicity of the widely used pain reliever and fever reducer, potentially leading to the development of safer alternatives or treatment strategies for acetaminophen-induced organ damage.

Upstream product

• 103-90-2 4-acetaminophenol 

Relevant academic research and scientific papers

Photochemical Oxygenation of Phenols by Pyrimidopteridine N-Oxide. Comparative Studies with Pyridazine and Isoalloxazine N-Oxides

1,3,7,9-Tetrabutylpyrimidopteridine-2,4,6,8(1H,3H,7H,9H)-tetraone 5-oxide 1 transfers its N-oxide oxygen to phenols, i.e., phenol 5, p-cresol 6, L-tyrosine methyl ester 7, and p-hydroxyacetanilide (acetaminophen) 8, under photochemical conditions to give the corresponding dihydric phenols as major products without any accompanying photochemical intramolecular rearrangements of the N-oxide group taking place.This oxygenation is reasonably explained in terms of a photo-induced single electron transfer (SET) followed by oxygen-atom transfer (the SET mechanism) which occurs via the initial formation of a charge-transfer complex between compound 1 and the phenols employed.Comparative experiments with 3,10-dibutylisoalloxazine 5-oxide 3 and 3-methylpyridazine 2-oxide 4 well demonstrate the simplicity and the mechanistic characteristics of the photochemistry of compound 1.