98977-55-0Relevant articles and documents
PH-Mediated Selective Synthesis of N-Allylic Alkylation or N-Alkylation Amines with Allylic Alcohols via an Iridium Catalyst in Water
Luo, Nianhua,Zhong, Yuhong,Shui, Hongling,Luo, Renshi
, p. 15509 - 15521 (2021/11/01)
Amination of allylic alcohols is an effective approach in the facile synthesis of N-allylic alkylation or N-alkylation amines. Recently, a series of catalysts were devised to push forward this transformation. However, current synthetic methods are typical
Palladium-catalyzed regio- and stereoselective β-arylation of tertiary allylic amines: Identification of potent adenylyl cyclase inhibitors
Ye, Zhishi,Dai, Mingji,Brust, Tarsis F.,Watts, Val J.
, p. 892 - 895 (2015/03/30)
Substituted allylic amines and their derivatives are key structural motifs of many drug molecules and natural products. A general, mild, and practical palladium-catalyzed β-arylation of tertiary allylic amines, one of the most challenging Heck arylation substrates, has been developed. The β-arylation products were obtained in excellent regio- and stereoselectivity. Moreover, novel and potent adenylyl cyclase inhibitors with the potential for treating neuropathic and inflammatory pain have been identified from the β-arylation products.