98988-21-7

Basic information

• Product Name: N-<2-(3-benzyloxy-4-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide
• CAS NO: 98988-21-7
• Molecular Weight: 405.494
• Mol File: 98988-21-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-<2-(3-benzyloxy-4-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-<2-(3-benzyloxy-4-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide(98988-21-7)
• EPA Substance Registry System: N-<2-(3-benzyloxy-4-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide(98988-21-7)

Safety Data

• Hazardous Substances Data: 98988-21-7(Hazardous Substances Data)

Upstream product

• 142066-41-9 2-(chloromethyl)-phenyl methanol 
• 67519-22-6 α-hydroxy-α'-cyano-o-xylene 
• 103-83-3 N,N'-dimethylbenzylamine 
• 4385-35-7 isochroman-3-one 
• 36455-21-7 3-benzyloxy-4-methoxyphenylethylamine 
• 63321-79-9 o-(N,N-dimethylaminomethyl)benzyl alcohol 

Downstream Products

• 98988-23-9 (+/-)-O-benzylisobharatamine 

Relevant articles and documents

A Convenient Total Synthesis of (+/-)-Bharatamine and (+/-)-Isobharatamine

N,N-Dimethylbenzylamine (1) on lithiation with n-butyllithium followed by reaction with paraformaldehyde gives the 2-hydroxymethyl derivative (2). 2 on successive reactions with ClCOOEt, KCN and alc.KOH followed by cyclisation furnishes isochroman-3-one (3).Condensation of 3 with phenylethylamines (4a) and (4b), followed by cyclisation (PCl5), reduction (NaBH4), and debenzylation (EtOH-HCl) gives (+/-)-bharatamine (6c) and (+/-)-3-hydroxy-4-methoxy-5,6,13,13a-tetrahydro-8H-dibenzoquinolizine (isobharatamine, 6d), respectively in high yields.