67519-22-6

Upstream product

• 5597-04-6 2-cyanomethylbenzoic acid methyl ester 
• 6627-91-4 2-cyanomethylbenzoic acid 
• 98590-71-7 α-chloro-α'-cyano-o-xylene 
• 87-41-2 2-benzofuran-1(3H)-one 
• 63321-79-9 o-(N,N-dimethylaminomethyl)benzyl alcohol 
• 103-83-3 N,N'-dimethylbenzylamine 
• 151-50-8 potassium cyanide 
• 142066-41-9 2-(chloromethyl)-phenyl methanol 

Downstream Products

• 952568-66-0 2-(cyanomethyl)benzyl methyl carbonate 
• 98988-20-6 N-<2-(4-benzyloxy-3-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide 
• 98988-21-7 N-<2-(3-benzyloxy-4-methoxyphenyl)-ethyl>-(2-hydroxymethyl)phenylacetamide 
• 98988-23-9 (+/-)-O-benzylisobharatamine 
• 98988-24-0 (S)-2-Benzyloxy-3-methoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline 
• 188255-05-2 2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline 
• 188255-07-4 2-(4-{2-[1-(Tetrahydro-pyran-2-yl)-1H-tetrazol-5-ylmethyl]-benzyloxy}-phenoxymethyl)-quinoline 
• 188255-06-3 2-(4-{2-[2-(Tetrahydro-pyran-2-yl)-2H-tetrazol-5-ylmethyl]-benzyloxy}-phenoxymethyl)-quinoline 
• 188255-03-0 5-(2-Bromomethyl-benzyl)-2-trityl-2H-tetrazole 
• 188255-01-8 [2-(2-Trityl-2H-tetrazol-5-ylmethyl)-phenyl]-methanol 
• 188255-08-5 5-(2-Bromomethyl-benzyl)-1-(tetrahydro-pyran-2-yl)-1H-tetrazole 
• 188255-04-1 5-(2-Bromomethyl-benzyl)-2-(tetrahydro-pyran-2-yl)-2H-tetrazole 
• 188255-02-9 5-(2-Bromomethyl-benzyl)-1H-tetrazole 
• 120128-20-3 2-[[4-[[2-(1H-tetrazol-5-ylmethyl)phenyl]methoxy]phenoxy]methyl]quinoline 

Relevant academic research and scientific papers

RENIN INHIBITORS

Compounds, pharmaceutical compositions, kits and methods are provided for use with Renin that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Process for producing isochromanones and intermediates thereof

(1) Methods for producing isochromanone compounds from o-xylene compounds as starting compounds through α-halogeno-o-xylene derivatives, α-cyano-o-xylene derivatives, and α-halogeno-α′-cyano-o-xylene derivatives, and (2) methods for producing isochromanone compounds from o-xylene compounds as starting compounds through α,α′-dihalogeno-o-xylene derivatives, α,α′-dihydroxy-o-xylene derivatives, α-halogeno-α′-hydroxy-o-xylene derivatives and α-cyano-α′-hydroxy-o-xylene derivatives, and methods for producing these intermediate compounds.

A convergent synthesis of an LTD4 antagonist, RG12525

An efficient, convergent synthesis of an LTD4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as well as novel preparation of 2 is described.

A Convenient Total Synthesis of (+/-)-Bharatamine and (+/-)-Isobharatamine

N,N-Dimethylbenzylamine (1) on lithiation with n-butyllithium followed by reaction with paraformaldehyde gives the 2-hydroxymethyl derivative (2). 2 on successive reactions with ClCOOEt, KCN and alc.KOH followed by cyclisation furnishes isochroman-3-one (3).Condensation of 3 with phenylethylamines (4a) and (4b), followed by cyclisation (PCl5), reduction (NaBH4), and debenzylation (EtOH-HCl) gives (+/-)-bharatamine (6c) and (+/-)-3-hydroxy-4-methoxy-5,6,13,13a-tetrahydro-8H-dibenzoquinolizine (isobharatamine, 6d), respectively in high yields.