98994-27-5Relevant academic research and scientific papers
Isothiourea-Catalyzed Enantioselective Functionalization of 2-Pyrrolyl Acetic Acid: Two-Step Synthesis of Stereodefined Dihydroindolizinones
Zhang, Shuyue,Taylor, James E.,Slawin, Alexandra M. Z.,Smith, Andrew D.
supporting information, p. 5482 - 5485 (2018/09/13)
Catalytic enantioselective functionalization of 2-pyrrolyl acetic acid with trichloromethyl enones using isothiourea catalysis is reported, leading to a range of stereodefined diesters and diamides after nucleophilic ring opening with either methanol or b
Organocatalytic Michael addition-lactonisation of carboxylic acids using α,β-unsaturated trichloromethyl ketones as α,β-unsaturated ester equivalents
Morrill, Louis C.,Stark, Daniel G.,Taylor, James E.,Smith, Siobhan R.,Squires, James A.,D'Hollander, Agathe C. A.,Simal, Carmen,Shapland, Peter,O'Riordan, Timothy J. C.,Smith, Andrew D.
, p. 9016 - 9027 (2015/02/19)
Isothiourea HBTM-2.1 catalyses the Michael addition-lactonisation of 2-aryl and 2-alkenylacetic acids and α,β-unsaturated trichloromethyl ketones. Ring-opening of the resulting dihydropyranones and subsequent alcoholysis of the CCl3 ketone with
Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam
Zhang, Jinlong,Liu, Xihong,Ma, Xiaojuan,Wang, Rui
supporting information, p. 9329 - 9331 (2013/10/01)
Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).
Highly efficient asymmetric epoxidation of electron-deficient α,β-enones and related applications to organic synthesis
Zheng, Changwu,Li, Yawen,Yang, Yingquan,Wang, Haifeng,Cui, Haifeng,Zhang, Junkang,Zhao, Gang
supporting information; experimental part, p. 1685 - 1691 (2011/02/25)
The asymmetric epoxidation of electrondeficient olefins has been achieved using inexpensive and readily available prolinols as catalysts with good to excellent yields and enantioselectivities. The utility of the resulting chiral epoxides was illustrated b
Two effective procedures for the synthesis of trichloromethyl ketones, useful precursors of chiral α-amino and α-hydroxy acids
Corey,Link,Shao
, p. 3435 - 3438 (2007/10/02)
Trichloroacetic acid can be converted to trichloromethyl ketones in good yield by two practical new procedures, one involving the catalyzed reaction of trichloroacetic acid with aldehydes at 23°C followed by oxidation and the other utilizing the coupling
Selected Methods for the Oxidation of 1,1,1-Trichloro-2-alkanols. An Efficient Modification Using Chromic Acid
Gallina, Carlo,Giordano, Cesare
, p. 466 - 468 (2007/10/02)
The effectiveness of thirteen largely applied procedures has been checked in the oxidation of 1,1,1-trichloropropan-2-ol.A new, simple, and efficient modification using chromic acid has been found for the preparation of representative trichloromethyl ketones.
