99009-58-2Relevant academic research and scientific papers
2-(Aminoalkyl)-5-nitropyrazoloacridines, a New Class of Anticancer Agents
Capps, David B.,Dunbar, James,Kesten, Suzanne R.,Shillis, Joan,Werbel, Leslie M.,et al.
, p. 4770 - 4778 (2007/10/02)
2-(Aminoalkyl)-5-nitropyrazoloacridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with hydrazines.Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia.Advanced studies led to the selection of 3bbb for clinical trial.
Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
-
, (2008/06/13)
Substituted 1-amino-4-nitroacridinones, their method of manufacture, pharmaceutical compositions and their use as antibacterial and antitumor agents are herein described.
Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use
-
, (2008/06/13)
Pyrazolo[3,4,5-kl]acridines are described as antibacterial agents and antitumor agents as well as pharmaceutical compositions and methods for their preparation.
