99033-35-9Relevant academic research and scientific papers
Synthesis and in vivo biological activity of large-ringed calixarenes against Mycobacterium tuberculosis
Goodworth, Kerry J.,Hervé, Anne-Cécile,Stavropoulos, Evangelos,Hervé, Gwénaelle,Casades, Isabel,Hill, Alison M.,Weingarten, Gordon G.,Tascon, Ricardo E.,Colston, M. Joseph,Hailes, Helen C.
experimental part, p. 373 - 382 (2011/03/20)
A series of large-ringed calix[6,7,8]arene analogues have been synthesised and their affect against Mycobacterium tuberculosis in vivo established. In general, when p-phenylcalixarenes and tert-butylcalixarenes were not functionalised at the lower rim, low biological activities were observed. However on going from partially to fully lower rim pegylated calixarenes the anti-mycobacterial properties improved. The addition of cyanopropoxy groups at the lower rim gave rise to low activities, whereas the addition of acetate moieties interestingly had pro-TB effects. Two upper rim sulfonated calixarenes showed promising properties. In the course of this work, a high yielding procedure to synthesise p-phenylcalix[7]arene was also established. Copyright
Calixarenes. 16. Functionalized Calixarenes: The Direct Substitution Route
Gutsche, C. David,Pagoria, Philip F.
, p. 5795 - 5802 (2007/10/02)
The base-induced condensation of p-phenylphenol and formaldehyde is shown to yield p-phenylcalixarene 3 and p-phenylcalixarene 5 as isolable products but no detectable amount of p-phenylcalixarene 1, contrary to earlier reports.As an alternative
