99069-48-4Relevant academic research and scientific papers
Asymmetric Transfer Hydrogenation of rac-α-(Purin-9-yl)cyclopentones via Dynamic Kinetic Resolution for the Construction of Carbocyclic Nucleosides
Zhang, Yi-Ming,Zhang, Qi-Ying,Wang, Dong-Chao,Xie, Ming-Sheng,Qu, Gui-Rong,Guo, Hai-Ming
, p. 2998 - 3002 (2019)
An asymmetric transfer hydrogenation via dynamic kinetic resolution of a broad range of rac-α-(purin-9-yl)cyclopentones was first developed. A series of cis-β-(purin-9-yl)cyclopentanols were obtained with up to 97% yield, >20/1 dr, and >99% ee. This also provides an efficient synthetic route to a variety of chiral carbocyclic nucleosides.
