99071-94-0Relevant articles and documents
Quinazolinone compounds
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, (2008/06/13)
Phosphate derivatives are disclosed of quinazolinone compounds having structural formula (I) or a pharmaceutically acceptable salt thereof, wherein X' represent hydroxyl, alkyl, alkoxy, or O-Z where Z is a phosphate or phosphate derivative; Y' represents
Resistance-modifying agents. 5.1 Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)
Griffin, Roger J.,Srinivasan, Sheila,Bowman, Karen
, p. 5247 - 5256 (2007/10/03)
Clinical studies concerning the role of poly(ADP-ribose) polymerase (PARP) in the repair of drug- and radiation-induced DNA damage have been impeded by the poor solubility, lack of potency, and limited specificity of currently available inhibitors. A seri
Quinazolones: Part XI - Effect of Substituents on Claisen Rearrangement of Allyloxyquinazolones
Sinha, S. K. P.,Kumar, Prashant
, p. 1182 - 1184 (2007/10/02)
The Claisen rearrangement of 7-allyloxy-8-methoxy-2-methyl-3-phenylquinazolin-4(3H)-one (I) gives the unusual products 6-allyl-2-ethyl-7,8-dihydroxy-3-phenylquinazolin-4(3H)-one and 7-ethyl-9-hydroxy-2-methyl-6-phenylfuroquinazolin-5(6H)-one (VIb) instead of the expected 6-allyl-7-hydroxy-8-methoxy-2-methyl-3-phenylquinazolin-4(3H)-one (II).