172462-98-5

Basic information

• Product Name: 2-N-Acetylamino-3-methoxybenzamide
• Synonyms: 2-N-Acetylamino-3-methoxybenzamide
• CAS NO: 172462-98-5
• Molecular Weight: 208.217
• Mol File: 172462-98-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-N-Acetylamino-3-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-N-Acetylamino-3-methoxybenzamide(172462-98-5)
• EPA Substance Registry System: 2-N-Acetylamino-3-methoxybenzamide(172462-98-5)

Safety Data

• Hazardous Substances Data: 172462-98-5(Hazardous Substances Data)

Upstream product

• 106782-78-9 3-methoxy-2-aminobenzamide 
• 75-36-5 acetyl chloride 

Downstream Products

• 104296-30-2 2,3-dimethyl-8-methoxyquinazolin-4-one 
• 99071-94-0 8-hydroxy-2,3-dimethyl-quinazolin-4(3H)-one 
• 90417-38-2 8-hydroxy-2-methyl-4(3H)-quinazolinone 
• 90915-45-0 8-methoxy-2-methyl-4-oxo-3,4-dihydroquinazoline 

Relevant articles and documents

NEUROLOGICALLY-ACTIVE COMPOUNDS

The present invention relates to neurologically-active compounds, being heterocyclic compounds having two fused 6-membered rings with a nitrogen atom at position 1 and a hydroxy or mercapto group at position 8 with at least one ring being aromatic. Also disclosed are processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.

Benzamide analogs useful as PARP (ADP-ribosyltransferase, ADPRT) DNA repair enzyme inhibitors

A range of 3-oxybenzamide compounds and related quinazolinone compounds are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed include 3-benzyloxybenzamides, 3-oxybenzamides in which a chain of 5 or more methylene groups terminate in a halogen atom or in a purin-9-yl moiety, certain benzoxazole-4-carboxamide compounds and certain quinazolinone compounds. In formula X and Y together may form a bride -X-Y- that represents the grouping (a), (b) or (c )wherein R5 is H, alkyl, aryl or aralkyl.