99072-43-2Relevant articles and documents
Backbone-Rigidified Oligo(m-phenylene ethynylenes)
Yang, Xiaowu,Yuan, Lihua,Yamato, Kazuhiro,Brown, Amy L.,Feng, Wen,Furukawa, Mako,Zeng, Xiao Cheng,Gong, Bing
, p. 3148 - 3162 (2004)
Oligo(m-phenylene ethynylenes) (oligo(m-PE)) with backbones rigidified by intramolecular hydrogen bonds were found to fold into well-defined conformations. The localized intramolecular hydrogen bond involves a donor and an acceptor from two adjacent benze
Cytotoxic compounds. Part 21. Chloro-, methoxy-, and methoxy-carbonyl-derivatives of (bis-2-chloroethylamino)-phenols and -anilines
Abela Medici, Anthony J.,Owen, Leonard N.,Sflomos, Constantine
, p. 2258 - 2263 (2007/10/09)
New or improved syntheses are described of some NN-bis-2-chloroethylanilines carrying both a free phenolic group and a methoxycarbonyl ring substituent. A study has been made of the hydroxyethylation, with ethylene oxide, of a variety of chloro-, methoxy-, and methoxycarbonyl-nitroanilines, and of methoxy- and methoxycarbonyl-N-acylphenylenediamines. Bishydroxyethylation was inhibited by an o-methoxycarbonyl group and by an o- or p-nitro-group, but otherwise the NN-bis-2-hydroxyethyl derivatives were obtained and subsequently converted into the NN-bis-2-chloroethyl compounds. Reduction of the nitro-group, or hydrolysis of the acylamino-group, in these dichlorides led to NN-bis-2-chloroethylanilines carrying both a free amino-group and also a methoxycarbonyl-, methoxy-, or chloro-group as ring substituents. The ring-substituted (bis-2-chloroethylamino)-phenols or -anilines are precursors of mustard urethanes having potential importance as anti-tumour agents.
