99082-58-3Relevant articles and documents
Synthesis and Stereochemistry of Stereoisomeric 1,3-Oxazino- and 1,3-Thiazinoisoquinolines
Fueloep, Ferenc,Bernath, Gabor,El-Gharib, M. S.,Kobor, Jenoe,Sohar, Pal,et al.
, p. 803 - 809 (2007/10/02)
Starting from the 6,7-dialkoxy-1--1,2,3,4-tetrahydroisoquinolines 2 and 3, the 4-imino-substituted 1-(hydroxymethyl)-9,10-dialkoxy-2H,4H-1,6,7,11b-tetrahydro-1,3-oxazino- and -thiazinoisoquinoline diastereomers 6a-c, 7a-c, 8a-c, 9a-c, 14, and 15 and the 4-substituted 1,6,7,11b-tetrahydro-1,3-oxazinoisoquinoline diastereomers 16-24 were prepared.The relative configurations and the predominant conformation of these products were determined by NMR spectroscopy and for 18 by X-ray diffraction methods.The prepared 1,3-oxazinoisoquinoline diastereomers have predominantly trans conformations (16, 18, 22, 23), whereas cis conformations (cis-A) prevail for 20, 21 and 24.Thus, the first evidence for either trans- or cis-A conformations in 1,3-oxazinoisoquinolines is presented.