99142-58-2

Upstream product

• 2433-85-4 4,5-dibromo-2-furancarboxaldehyde 
• 71-43-2 benzene 
• 98-80-6 phenylboronic acid 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 13803-39-9 5-phenylfuran-2-carbaldehyde 

Downstream Products

• 1092976-32-3 4-(4-methoxyphenyl)-5-phenyl-2-furaldehyde 
• 594815-22-2 3-(4-chloro-phenyl)-4-(5-ethoxycarbonyl-furan-2-ylmethyl)-2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 
• 594815-26-6 3-(4-chloro-phenyl)-4-(2-morpholin-4-yl-ethyl)-2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 
• 594815-27-7 3-(4-chloro-phenyl)-2-phenyl-4-(2-pyrrolidin-1-yl-ethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 
• 594815-23-3 3-(4-chloro-phenyl)-2-phenyl-4-(tetrahydro-pyran-2-ylmethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 
• 594815-25-5 3-(4-chloro-phenyl)-4-(2-diethylamino-ethyl)-2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 
• 594815-24-4 3-(4-chloro-phenyl)-4-(2-methyl-thiazol-4-ylmethyl)-2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Antibacterial and antifungal properties of guanylhydrazones

A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus A

SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE

The present application relates to novel substituted bicyclic heteroaryl compounds, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or proph

Synthesis of a novel series of tetra-substituted furan[3,2-b]pyrroles

Furan[3,2-b]pyrroles are important isosteres for the indole scaffold in which the benzene ring is replaced by the furan ring. A series of novel tetra-substituted furan[3,2-b]pyrroles was synthesized from a simple furaldehyde. The divergent synthesis allows for substitution on multiple positions on the scaffold, creating the potential for the formation of large libraries.

PHOTOCHEMICAL ARYLATION OF FURANS AND THIOPHENES

The photochemical behaviour of furan and thiophene is discussed with special attention to photoarylation of thiophene.The irradiation of 5-bromofuran-2-carbaldehyde, 41, in benzene gave good yields of the corresponding 5-phenyl derivative 42.The reaction 41--->42 has been studied considering the photochemical behaviour changing both the position of the halogen on the furan ring and the effect of the solvent.Kinetic and spectroscopic data are in agreement with the formation of a transient triplet exciplex in this type of reactions.The use of both the iodo derivative 50 and acetonitrile as solvent allowed the conversion to be optimized.On the contrary, the irradiation of 41 in diethyl ether or in an amine furnished the dehalogenation product 53.Photoarylation can be extended to thiophene derivatives and aromatic or heteroaromatic donors.The reaction also occurs with halothiophenes or thiazoles as donors, or by using halothiophene carboesters as acceptors.On the contrary, halothiophene carbonitriles are unreactive under similar conditions.Some applications to the synthesis of naturally occurring polythiophenes are reported.The target compounds were obtained through photoarylation and subsequent reaction with alkynes in the presence of palladium(0) complexes as catalysts.The role of polythiophenes in the environment is discussed.The hypothesis that the bioactivity of these compounds is related to the capability to be singlet-oxygen sensitizers is supported by the finding that all the bithiophenes synthesized are singlet-oxygen sensitizers.

Photochemical Synthesis of 3- and 5-Aryl-2-furyl Derivatives

Irradiation of 3- and 5-bromofuran-2-carbaldehyde in aromatic solutions furnished, in good yield, 3- and 5-aryl-2-furyl derivatives.Analogously, 4,5-dibromofuran-2-carbaldehyde (3) and 4,5-dibromo-2-furyl methyl ketone (5) are useful starting materials for the synthesis of the previously unknown 5-aryl-4-bromo-2-furyl derivatives.Irradiation (in diethyl ether) of the above compounds furnished the debromination products in high yield.This method represents an efficient procedure for the synthesis of 4-bromofuran-2-carbaldehyde (4).