99179-72-3

Basic information

• Product Name: 4-Methoxy-1,3-benzenediol 3-Acetate
• Synonyms: 4-Methoxy-1,3-benzenediol 3-Acetate;4-Methoxy-resorcinol 3-Acetate
• CAS NO: 99179-72-3
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.1733
• Product Categories: Aromatics;Intermediates
• Mol File: 99179-72-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Dichloromethane
• CAS DataBase Reference: 4-Methoxy-1,3-benzenediol 3-Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-1,3-benzenediol 3-Acetate(99179-72-3)
• EPA Substance Registry System: 4-Methoxy-1,3-benzenediol 3-Acetate(99179-72-3)

Safety Data

• Hazardous Substances Data: 99179-72-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

4-Methoxy-1,3-benzenediol 3-Acetate (cas# 99179-72-3) is a compound useful in organic synthesis.

Upstream product

• 621-59-0 isovanillin 
• 108-24-7 acetic anhydride 
• 881-57-2 isovanillin acetate 

Downstream Products

• 1415914-34-9 (E)-3-(dimethylamino)-1-(2-hydroxy-5-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl)prop-2-en-1-one 
• 1252801-60-7 1-(2-hydroxy-5-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl)ethanone 
• 7298-21-7 1-(2,4-dihydroxy-5-methoxyphenyl)ethan-1-one 
• 103203-40-3 (4-hydroxy-2,5-dimethoxy-phenyl)-glyoxylic acid 
• 18113-18-3 2,5-dimethoxyphenol 
• 27257-06-3 2,5-dimethoxyphenyl acetate 
• 6100-60-3 4-methoxybenzene-1,3-diol 

Relevant articles and documents

SYNTHESIS OF 13C-LABELLED ESTROGEN ANALOGUES

There is provided a method of producing novel 13C-labelled estrogen analogues. The method preferably proceeds via an intermediate A or B or which is a mixture of (A) or (B): wherein a13C atom is located at one or more of positions 1, 2, 3 or 4 and wherein R is an optionally substituted alkane, alkene, alkyne or aryl group. Preferably R is -CH2Ph. An alternative preferred intermediate compound is 13C-resorcinol.

Mechanistic Studies of Selective Catechol Formation from o-Methoxyphenols using a Copper(II)-Ascorbic Acid-Dioxygen System

Mechanistic details of selective conversion of o-methoxyphenols to the corresponding catechols using a Cu2+-ascorbic acid-O2 system, were studied. 2,5-Dimethoxyphenol was converted predominantly to the o-demethylated compound and partially to the m-demethylated one.Anisole with no phenolic hydroxy group was much less reactive.When guaiacol (1). guaiacol and 2-methoxy-6-methoxyphenol was used as substrates, moderate intermolecular and intramolecular kinetic isotope effects were observed (1.4-1.9). Catechol was derived from 1 in nine-fold excess over catechol when the reaction was run in an 18O2 atmosphere with natural water as a solvent, though no catechol was formed when using natural O2 and H218O.It was determined that the Cu2+-ascorbic acid-O2 system operates in a monooxygenase mode because the oxygen atom of dioxygen (not water) was incorporated into the products, and this oxidative conversion proceeded mainly via ipso-substitution at the methoxy position, probably with hydroxyl radical coordinated to the cupric ion as the active oxygen species.