1124174-16-8

Upstream product

• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 99183-13-8 methyl 2-(4-hydroxycyclohexyl)acetate 
• 66405-41-2 (4-oxo-cyclohexyl)-acetic acid methyl ester 
• 317338-46-8 methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)acetate 
• 172270-85-8 8-(methoxyformylmethylene)-1,4-dioxaspiro[4.5]decane 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 1252886-56-8 [cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexyl]acetic acid 
• 1268239-60-6 6-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester 
• 1268239-62-8 C₂₆H₂₉F₂N₃O₅ 
• 1268239-16-2 trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester 
• 1268239-40-2 trans-6-[3-(2-chloro-3-methyl-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester 
• 1268239-61-7 6-amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-methoxycarbonylmethyl-cyclohexyl ester 
• 1268239-14-0 trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester 
• 1268239-64-0 C₂₆H₂₉F₂N₃O₅ 
• 1268239-88-8 C₂₇H₃₂ClN₃O₅ 
• 1415573-11-3 trans benzyl 4-(4-(2-methoxy-2-oxoethyl)cyclohexyloxy)piperidine-1-carboxylate 
• 1415573-12-4 methyl 2-((1r,4r)-4-(piperidin-4-yloxy)cyclohexyl) acetate 

Relevant academic research and scientific papers

A biocatalytic/reductive etherification approach to substituted piperidinyl ethers

A synthetically useful protocol has been developed for the preparation of highly functionalized piperidinyl ethers. Biocatalytic reduction of cyclhexanones 7, 10, and 14 allows for the preparation of both cis- and trans diastereomers with an extremely high degree of stereochemical control. Reductive etherification of the corresponding trimethylsilylethers with 1-(benzyloxycarbonyl)-4-piperidinone 17 in the presence of triethylsilane and catalytic TMSO-Tf provides the desired piperidinyl ethers in good to excellent yields. Finally hygrogenolysis of the nitrogen protecting group leads to piperidinyl ethers in near quantitative yields. Application of the methodology to a range of piperidinyl ethers, including the core scaffolds of diphenylpyraline and ebastine, is also described.

IMIDAZOLE DERIVATIVES

Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS

The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-is