99191-71-6

Basic information

• Product Name: HEXANE-1,6-DIYLBIS(METHYLCARBAMIC CHLORIDE)
• Synonyms: HEXANE-1,6-DIYLBIS(METHYLCARBAMIC CHLORIDE);1,6-Hexanediylbis[methylcarbamic chloride]
• CAS NO: 99191-71-6
• Molecular Formula: C₁₀H₁₈Cl₂N₂O₂
• Molecular Weight: 269.16812
• Mol File: 99191-71-6.mol

Chemical Properties

• Boiling Point: 402.9±28.0 °C(Predicted)
• Appearance: /
• Density: 1.195
• PKA: -1.57±0.70(Predicted)
• CAS DataBase Reference: HEXANE-1,6-DIYLBIS(METHYLCARBAMIC CHLORIDE)(CAS DataBase Reference)
• NIST Chemistry Reference: HEXANE-1,6-DIYLBIS(METHYLCARBAMIC CHLORIDE)(99191-71-6)
• EPA Substance Registry System: HEXANE-1,6-DIYLBIS(METHYLCARBAMIC CHLORIDE)(99191-71-6)

Safety Data

• Hazardous Substances Data: 99191-71-6(Hazardous Substances Data)

Usage

Uses

Used in Pesticide Production:
HEXANE-1,6-DIYLBIS(METHYLCARBAMIC CHLORIDE) is used as an intermediate in the production of carbamate insecticides such as aldicarb and carbofuran. It plays a crucial role in the synthesis of these insecticides, which are widely used in agriculture to control pests and protect crops.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, HEXANE-1,6-DIYLBIS(METHYLCARBAMIC CHLORIDE) is used as a potential cross-linking agent in drug delivery systems. Its ability to form covalent bonds with other molecules makes it a valuable component in the development of advanced drug delivery systems that can improve the efficacy and targeted delivery of pharmaceuticals.

Upstream product

• 75-44-5 phosgene 
• 111-18-2 N,N,N',N'-tetramethylhexamethylenediamine 
• 13093-04-4 N,N'-dimethyl-1,6-hexanediamine 

Downstream Products

• 117688-88-7 N,N''-1,6-(hexanediyl)bis[N'-cyclohexyl-N'-[(cyclohexylimino)(4-morpholinyl)methyl]-N-methylurea] 
• 95701-58-9 Methyl-{6-[methyl-(pyridin-3-yloxycarbonyl)-amino]-hexyl}-carbamic acid pyridin-3-yl ester 
• 15876-67-2 BC 51 
• 96967-90-7 N,N'-dimethyl-N,N'-hexanediyl-bis-carbamic acid bis-(3-dimethylamino-phenyl ester) 

Relevant articles and documents

Preparation method of high-purity distigmine bromide

The invention relates to a preparation method of high-purity distigmine bromide and aims to provide a method being economical, environmentally friendly, convenient to operate and suitable for large-scale industrial production for synthesizing high-purity and high-yield distigmine bromide. In the synthesis method, the volume ratio of acetonitrile to acetone for refining distigmine bromide is (20-50): 1, preferably (25-30): 1.

Synthesis of acylguanidine analogues: inhibitors of ADP-induced platelet aggregation

Routine screening of compounds for inhibition of ADP-induced platelet aggregation in vitro revealed that 1'-hexamethylenebis[3-cyclohexyl-3-[(cyclohexylimino)(4-morpholinyl)methyl] urea] was active and represented the first example of a bis(acylguanidine) with possible antithrombotic activity. In order to develop a structure-activity relationship for this class of compounds, we synthesized a number of new bis(acylguanidines). These were tested in vitro, and several analogues were also active. Ex vivo testing revealed that compounds 22, 41, 58, and 70-73 were orally active in rats or guinea pigs.