99197-05-4

Upstream product

• 6853-57-2 4-pentylbenzaldehyde 
• 538-68-1 pentylbenzene 

Downstream Products

• 110683-13-1 (E)-N-(2-Cyanomethoxy-phenyl)-3-(4-pentyl-phenyl)-acrylamide 
• 110683-15-3 (E)-3-(4-Pentyl-phenyl)-N-[2-(1H-tetrazol-5-ylmethoxy)-phenyl]-acrylamide 
• 110683-14-2 {2-[(E)-3-(4-Pentyl-phenyl)-acryloylamino]-phenoxy}-acetic acid 
• 110683-12-0 {2-[(E)-3-(4-Pentyl-phenyl)-acryloylamino]-phenoxy}-acetic acid ethyl ester 

Relevant academic research and scientific papers

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.