99198-89-7

Upstream product

• 501-53-1 benzyl chloroformate 
• 54288-70-9 4-bromopiperidine hydrobromide 
• 5299-60-5 6-hydroxy-hexanoic acid ethyl ester 
• 122822-50-8 6-<(4-methylbenzenesulfonyl)oxy>hexanoic acid, ethyl ester 
• 166953-64-6 benzyl 4-bromo-1-piperidinecarboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 99198-86-4 ethyl (R)-6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate 
• 99198-85-3 ethyl 5-(1-benzyloxycarbonyl-4-piperidyl)pentanoate 
• 99198-84-2 3-(1-benzyloxycarbonyl-4-piperidyl)pentanoic acid 
• 99198-61-5 ethyl 6-(1-benzyloxycarbonyl-4-piperidyl)-2-oxohexanoate 

Downstream Products

• 99198-68-2 ethyl 7-(1-benzyloxycarbonyl-4-piperidyl)-2-oxoheptanoate 
• 100303-32-0 tert-butyl 3(R)-[6-(1-benzyloxycarbonyl-4-piperidyl)-1(S)-ethoxycarbonylhexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate 
• 100303-31-9 4-[(R)-6-((R)-5-tert-Butoxycarbonylmethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-6-ethoxycarbonyl-hexyl]-piperidine-1-carboxylic acid benzyl ester 
• 99198-70-6 4-[(S)-6-((S)-9-tert-Butoxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-6-ethoxycarbonyl-hexyl]-piperidine-1-carboxylic acid benzyl ester 
• 99198-69-3 tert-butyl 3(S)-[6(1-benzyloxycarbonyl-4-piperidyl)-1(R)-ethoxycarbonylhexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate 

Relevant academic research and scientific papers

Copper-Catalyzed Reductive Cross-Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides

A copper-catalyzed reductive cross-coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost-effective construction of aryl-alkyl and alkyl-alkyl C=C bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo- or heterocycles, such as 2,3-dihydrobenzofuran and benzochromene derivatives.

Condensed seven-membered ring compounds, their production and use

Novel condensed seven-membered ring compounds of the formula: STR1 [wherein R1 and R2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R3 and R5 are independently hydrogen, lower alkyl or aralkyl; R4 is hydrogen or lower alkyl; R6 is a condensed or non-condensed hetero-alicyclic containing at least one atom of N, O and S as a ring-forming atom which may be substituted; A is an alkylene chain; n is 1 or 2] and salts thereof. These compounds exhibit inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases, such as hypertension, cardiopathy and cerebral apoploxy.

3-Amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives

Novel 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives of the formula STR1 [wherein R1 and R2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R3 is hydrogen, optionally substituted lower alkyl or optionally substituted aralkyl; R4 is hydrogen, optionally substituted alkyl, optionally substituted aralkyl or optionally substituted cycloalkylalkyl; Y is a carboxyl group which may be esterified or amidated; m is 1 or 2] and salts thereof. These compounds and salts thereof exhibits inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases (e.g. hypertension, cardiopathy, cerebral apoploxy).