99216-76-9

Upstream product

• 99216-72-5 Boc-L-Thr(Ms)-OMe 
• 99216-73-6 N-<(1R,2R)-1-(Hydroxymethyl)-2-(methanesulfonyloxy)ethyl>-1-(1,1-dimethylethoxy)methanamide 
• 99216-71-4 (2S,3S)-N-Boc-2-(hydroxymethyl)-3-methylaziridine 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 60538-19-4 N-(tert-butoxycarbonyl)-l-threonine methyl ester 
• 99216-75-8 (2S,3S)-2-Methanesulfonyloxymethyl-3-methyl-aziridine-1-carboxylic acid tert-butyl ester 
• 829-85-6 diphenylphosphane 

Relevant academic research and scientific papers

Asymmetric Hydrogenation Catalyzed by Rhodium Complex with a New Chiral Bisphosphine Derived from L-Threonine

A new chiral bisphosphine, (2R,3S)-1,2-bis(diphenylphosphino)-3-'Boc-aminobutane (RS-5), was prepared from L-threonine.Mesylation of 'Boc-L-threonine methyl ester (2) and subsequent reduction with sodium borohydride gave the alcohol (10), which was treated with potassium carbonate to afford a key intermediate, (2S,3S)-1-'Boc-3-methyl-2-aziridinemethanol (SS-7b).Mesylation of SS-7b, followed by treatment with sodium diphenylphosphide afforded the new chiral bisphosphine (RS-5).The structure of RS-5 was confirmed by the X-ray analysis of its crystalline CuCl complex (RS-12).The cationic rhodium (I) complexes prepared from RS-5 and RS-12 are efficient asymmetric hydrogenation catalysts for N-acyldehydroamino acids, giving (S))-N-acylamino acids in high optical yields (83-94percentee).