99221-24-6

Basic information

• Product Name: 1,2-dimethoxy-4-(2-benzyloxyethyl)benzene
• Synonyms: 1,2-dimethoxy-4-(2-benzyloxyethyl)benzene
• CAS NO: 99221-24-6
• Molecular Weight: 272.344
• Mol File: 99221-24-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-dimethoxy-4-(2-benzyloxyethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dimethoxy-4-(2-benzyloxyethyl)benzene(99221-24-6)
• EPA Substance Registry System: 1,2-dimethoxy-4-(2-benzyloxyethyl)benzene(99221-24-6)

Safety Data

• Hazardous Substances Data: 99221-24-6(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 

Downstream Products

• 523-02-4 (S)-(-)-norcoralydine 
• 406215-72-3 2-Methoxy-naphthalene-1-sulfinic acid [(S)-1-[2-(2-benzyloxy-ethyl)-4,5-dimethoxy-phenyl]-2-(2-cyano-4,5-dimethoxy-phenyl)-ethyl]-amide 
• 406215-59-6 Toluene-4-sulfonic acid 2-[2-((S)-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-4,5-dimethoxy-phenyl]-ethyl ester 
• 406215-98-3 (S)-(-)-3-[2-(2-benzyloxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 406215-57-4 (S)-(-)-3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 406215-49-4 4,5-dimethoxy-2-(2-benzyloxyethyl)benzaldehyde 
• 406215-48-3 1-bromo-4,5-dimethoxy-2-(2-benzyloxyethyl)benzene 

Relevant articles and documents

Asymmetric synthesis of the protoberberine alkaloid (s)-(-)-xylopinine using enantiopure sulfinimines

A concise enantioselective synthesis of (S)-(-)-xylopinine (1) is described involving the addition of the laterally lithiated derivative of o-tolunitrile of 16 to enantiopure sulfinimine (+)-14. Treatment of the resulting cyano sulfinamide adduct (-)-17b with DIBAL-H accomplishes five operations in a single pot and furnishes the cyclic imine (+)-18 in good yield. Reduction and cyclization affords (S)-(-)-1. Alternatively basic hydrolysis of 17b,c gives isoquinolone 21 that is cyclized and reduced to give (S)-(-)-1.