99226-02-5Relevant academic research and scientific papers
Preparation method of 2-(2-methoxyphenyl)-5-oxotetrahydrofuran-3-carboxylic acid
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Paragraph 0016; 0024-0029, (2017/08/31)
The invention discloses a high-efficiency synthesis method of 2-(2-methoxyphenyl)-5-oxotetrahydrofuran-3-carboxylic acid. The 2-(2-methoxyphenyl)-5-oxotetrahydrofuran-3-carboxylic acid is obtained through a reaction of o-methoxybenzaldehyde and succinic anhydride used as raw materials in an aprotic inert solvent by adopting cadmium / triethylamine as a catalyst. The synthesis method has the advantages of cheap and easily available reaction raw material, simple and easily controlled reaction process, few product post-treatment steps, high yield, high product purity, low cost, and suitableness for large-scale industrial production. The preparation method overcomes a shortcoming that a high yield is reached only through using high-temperature dewatering needed by zinc chloride used as a catalyst in the prior art, and cadmium chloride does not require high temperature roasting dewatering, avoids the difficult material transfer condition, and is suitable for industrial production.
PPAR Modulators
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Page/Page column 12-14; 17, (2011/08/04)
1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections.
1,3-dioxan-5-yl-hexenoic acids
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, (2008/06/13)
The invention provides a novel group of 4(Z)-6-([2,4,5-cis]-2-alkyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)hexenoic acids of formula I wherein R is branched alkyl of 3-5 carbon atoms and one of X and Y is hydrogen or fluoro and the other is hydrogen, and their
