99240-01-4Relevant academic research and scientific papers
Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity
Luo, Min,Groaz, Elisabetta,De Jonghe, Steven,Snoeck, Robert,Andrei, Graciela,Herdewijn, Piet
, p. 381 - 385 (2018)
A series of amidate prodrugs of cyclic 9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (cHPMPA) featuring different amino acid motifs were synthesized. All phosphonamidates derived from (S)-cHPMPA displayed a broad spectrum activity against herpesviruses
NOVEL PRODRUGS OF NUCLEOSIDE PHOSPHONATES
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Page/Page column 21, (2018/10/19)
The present invention relates to novel phosphonoamidate prodrugs. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses such as the herpes simplex virus 1, herpes simplex virus 2, human cytomegalovirus, varicella zoster virus, vaccinia virus and adenovirus.
