99255-23-9

Basic information

• Product Name: 2-Propanone, 1-[5-methoxy-2-(phenylethynyl)phenyl]-
• CAS NO: 99255-23-9
• Molecular Formula: C18H16O2
• Molecular Weight: 264.324
• Mol File: 99255-23-9.mol

Chemical Properties

• CAS DataBase Reference: 2-Propanone, 1-[5-methoxy-2-(phenylethynyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanone, 1-[5-methoxy-2-(phenylethynyl)phenyl]-(99255-23-9)
• EPA Substance Registry System: 2-Propanone, 1-[5-methoxy-2-(phenylethynyl)phenyl]-(99255-23-9)

Safety Data

• Hazardous Substances Data: 99255-23-9(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 99254-54-3 l-(2-iodo-5-methoxyphenyl)-2-propanone 

Downstream Products

• 112399-18-5 N-<2-<5-methoxy-2-(phenylethynyl)phenyl>-1-methylethyl>-1-naphthaleneethanamine 
• 99540-07-5 Hexyl-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-methyl-amine 
• 99255-06-8 [2-(3,4-Dichloro-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine 
• 99256-81-2 N-[2-(3,5-dimethoxyphenyl)ethyl]-5-methoxy-N,α-dimethyl-2-(phenylethynyl)benzeneethanamine 
• 112399-24-3 [2-(5-Methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-methyl-(2-naphthalen-1-yl-ethyl)-amine 
• 99255-28-4 [2-(3,4-Dichloro-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-methyl-amine 
• 99256-80-1 [2-(3-Methoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-methyl-amine 
• 99256-44-7 [2-(3-Chloro-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-methyl-amine 
• 99256-63-0 [2-(3-Methoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine 
• 99256-42-5 [2-(3-Chloro-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine 
• 99255-40-0 (3,4-Dimethoxy-benzyl)-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-methyl-amine 
• 99256-15-2 [2-(4-Chloro-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine 
• 99256-57-2 N-[2-(3,5-dimethoxyphenyl)ethyl]-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamine 
• 99256-13-0 [2-(5-Methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-[2-(4-nitro-phenyl)-ethyl]-amine 

Relevant articles and documents

2-Ethynylbenzenealkanamines. A new class of calcium entry blockers

A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the 'Langendorff' guinea pig heart in vitro. They have been shown to exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines.

Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives

Acetylenes of the formula (I): STR1 wherein Y, m, R1, R2 q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.

Cis & trans stilbenes and their composition for the treatment of hypertension

Stilbenes of the formula (I): wherein Y, m, R1, R2, q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias.