99254-54-3

Upstream product

• 144828-84-2 N-methoxy-1′-(3-methoxyphenyl)-N-methylacetamide 
• 29114-51-0 4-(3-methoxyphenyl)butan-2-one 
• 3027-13-2 1-(3-methoxyphenyl)propan-2-one 

Downstream Products

• 99255-80-8 [2-(2-Iodo-5-methoxy-phenyl)-1-methyl-ethyl]-phenethyl-amine 
• 99255-23-9 1-[5-Methoxy-2-(phenylethynyl)phenyl]-2-propanone 
• 112399-37-8 2-iodo-5-methoxy-N,alphadimethyl-N-[(phenyl)butyl]benzeneethanamine oxalate 
• 100634-30-8 N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-N,alphadimethylbenzeneethanamine oxalate 
• 13391-27-0 5-methoxy-2-methylbenzofuran 
• 99255-62-6 [2-(3,4-Dimethoxy-phenyl)-ethyl]-{2-[2-(4-methanesulfinyl-phenylethynyl)-5-methoxy-phenyl]-1-methyl-ethyl}-methyl-amine 
• 99255-52-4 4-[2-(2-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-4-methoxy-phenylethynyl]-benzonitrile 
• 99255-61-5 [2-(3,4-Dimethoxy-phenyl)-ethyl]-{2-[5-methoxy-2-(4-methylsulfanyl-phenylethynyl)-phenyl]-1-methyl-ethyl}-methyl-amine 
• 99256-89-0 [2-(3,4-Dimethoxy-phenyl)-ethyl]-{2-[5-methoxy-2-(4-trifluoromethyl-phenylethynyl)-phenyl]-1-methyl-ethyl}-methyl-amine 
• 112399-28-7 {2-[2-(4-Chloro-phenylethynyl)-5-methoxy-phenyl]-1-methyl-ethyl}-[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amine 
• 99255-57-9 [2-(3,4-Dimethoxy-phenyl)-ethyl]-{2-[2-(4-fluoro-phenylethynyl)-5-methoxy-phenyl]-1-methyl-ethyl}-methyl-amine 
• 99255-26-2 [2-(3,4-Dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-methyl-amine 
• 99255-02-4 [2-(3,4-Dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine 
• 99255-51-3 [2-(3,4-Dimethoxy-phenyl)-ethyl]-[2-(2-iodo-5-methoxy-phenyl)-1-methyl-ethyl]-methyl-amine 

Relevant academic research and scientific papers

Synthesis of Benzo[ b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis

One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogues, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.

2-Ethynylbenzenealkanamines. A new class of calcium entry blockers

A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the 'Langendorff' guinea pig heart in vitro. They have been shown to exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines.

Acetylene amines and their use as vasodilators and antihypertensives

Acetylenes of the following formula (I): STR1 wherein Y, m, R1, R2, R3, n and R4 are defined herein and R5 is hydrogen, alkyl, cycloalkyl or substituted alkyl are useful vasodilators and antihypertens

Cis & trans stilbenes and their composition for the treatment of hypertension

Stilbenes of the formula (I): wherein Y, m, R1, R2, q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias.

Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives

Acetylenes of the formula (I): STR1 wherein Y, m, R1, R2 q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.