99294-92-5

Upstream product

• 76883-48-2 quinuclidin-3-amine 
• 61694-98-2 5-chloro-2-methoxy-4-(methylamino)benzoic acid 
• 110-17-8 (2E)-but-2-enedioic acid 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant academic research and scientific papers

2-Alkoxy-n-(1-azabicyclo(2.2.2)-oct-3-yl) benzamides and thiobenzamides having an antischizophrenic activity

2-Alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides having the formula wherein X is oxygen or sulphur; R1 is loweralkyl; and R2 is hydrogen, halo, 4,5-benzo, alkoxy or Am wherein Am is amino, methylamino or dimethylamino, and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof have antischizophrenic activity.

Method of using 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide-N-oxides to control emesis caused by anticancer drugs

A method of controlling emesis caused by anticancer drugs with 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl) benzamide-N-oxides having the formula: STR1 wherein R1 is loweralkyl, and R2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, methylsulfonyl, loweralkoxy or Am and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof is disclosed.

Anxiolytic-N-(1-Azabicyclo[2.2.2]Oct-3-yl) Benzamides and Thobenzamides

Compounds of general formula I: wherein:, , X represents oxygen or sulphur;, R1 represents loweralkyl;, R2 represents hydrogen, halo, 4,5-benzo, loweralkoxy, amino, methylamino or dimethylamino;, R3 represents hydrogen or loweralkyl;, and, n is 1 or 2, , and their pharmaceutically acceptable acid addition salts have anxiolytic activity. In particular, they have activity against anxiety induced by the withdrawal from ingested substances such as narcotics (eg cocaine), alcohol and nicotine.

Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes

A pharmaceutical method for improving memory or correcting memory deficiency is disclosed, utilizing compounds having the formula: STR1 wherein n1, n2, n3, and n4 =0 to 3; R1, R2, R3, and R4 =H, loweralkyl or phenyl; R5 =H or loweralkyl; X=O or S; Ar=phenyl, substituted phenyl, pyridinyl, furanyl, thienyl, methoxy-1H-benzotriazolyl, indolinyl, methoxyindolinyl, methoxypyrimidinyl, amino-methoxypyrimadinyl, 1,3-benzodioxolyl, or naphthalenyl, and the pharmaceutically acceptable acid addition salts, hydrates and alcoholates thereof.