99298-93-8

Upstream product

• 99298-92-7 2-(5-Ethyl-3-phenyl-isoxazol-4-yl)-3,4,4-trimethyl-4,5-dihydro-oxazol-3-ium; iodide 
• 91569-55-0 5-ethyl-3-phenylisoxazole-4-carboxylic acid 
• 1136-45-4 5-methyl-3-phenylisoxazol-4-carboxylic acid 
• 99299-07-7 5-ethyl-3-phenylisoxazole-4-carbinol 

Downstream Products

• 111556-67-3 diethyl 2,6-dimethyl-4-(5-ethyl-3-phenylisoxazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant academic research and scientific papers

Cardioactivity and solid-state structure of two 4-isoxazolyldihydropyridines related to the 4-aryldihydropyridine calcium-channel blockers

Diethyl 2,6-dimethyl-4-(5-ethyl-3-phenylisoxazol-4-yl)-1,4-dihydropyridine-3,5-dic arboxylate (5) and diethyl 2,6-dimethyl-4-(5-isopropyl-3-phenylisoxazol-4-yl)-1,4-dihydropyridine-3,5 -dicarboxylate (6) were synthesized, and their molecular structures we

Metalation of Isoxazolyloxazolines, a Facile Route to Functionally Complex Isoxazoles: Utility, Scope, and Comparison to Dianion Methodology

2-(5'-Alkylisoxazol-4'-yl)-Δ2-oxazoline was metalated at the C-5' alkyl group, and the lithio anion was quenched with a variety of electrophiles.Alkyl halides, aldehydes, and acylpyridinium salts were used as electrophiles.The lithio anion was oxygenated with MOOPH or N-(phenylsulfonyl)oxaziridene.The isoxazolyloxazoline system was converted to the isoxazolyl carboxylic acid, aldehyde, ketone, and chiral oxazoline.The isoxazolyloxazoline was formed, metalated, and deprotected in synthetically useful yields and represents a facile entry into functionally complex isoxazoles.To determine the necessity of the oxazoline protection/deprotection scheme, dianions of isoxazole-4-carboxylic acids were studied.The dianion method was found to be more efficient for simple alkyl halides, but limited in scope.