91569-55-0

Basic information

• Product Name: 4-Isoxazolecarboxylic acid, 5-ethyl-3-phenyl-
• CAS NO: 91569-55-0
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224
• Mol File: 91569-55-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-Isoxazolecarboxylic acid, 5-ethyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isoxazolecarboxylic acid, 5-ethyl-3-phenyl-(91569-55-0)
• EPA Substance Registry System: 4-Isoxazolecarboxylic acid, 5-ethyl-3-phenyl-(91569-55-0)

Safety Data

• Hazardous Substances Data: 91569-55-0(Hazardous Substances Data)

Upstream product

• 698-16-8 benzohydroximoyl chloride 
• 4949-44-4 ethyl propanoylacetate 
• 1136-45-4 5-methyl-3-phenylisoxazol-4-carboxylic acid 
• 74-88-4 methyl iodide 
• 93599-45-2 4-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-5-ethyl-3-phenyl-isoxazole 
• 16883-16-2 5-methyl-3-phenylisoxazole-4-carbonyl chloride 
• 929890-04-0 5-Ethyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester 
• 99298-89-2 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide 
• 93599-37-2 4-(4',5'-dihydro-4',4'-dimethyl-Δ²-oxazolin-2-yl)-5-methyl-3-phenylisoxazole 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 

Downstream Products

• 92029-28-2 5-isopropyl-3-phenyl-isoxazole-4-carboxylic acid 
• 99299-07-7 5-ethyl-3-phenylisoxazole-4-carbinol 
• 943327-53-5 2-bromo-1-(5-ethyl-3-phenyl-isoxazol-4-yl)-ethanone 
• 99299-09-9 (5-isopropyl-3-phenylisoxazol-4-yl)methanol 
• 111556-67-3 diethyl 2,6-dimethyl-4-(5-ethyl-3-phenylisoxazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 99298-93-8 5-ethyl-3-phenylisoxazole-4-carboxaldehyde 
• 96436-09-8 5-ethyl-3-phenyl-isoxazole-4-carboxylic acid amide 

Relevant articles and documents

Non-Decarboxylative Ruthenium-Catalyzed Rearrangement of 4-Alkylidene-isoxazol-5-ones to Pyrazole- and Isoxazole-4-carboxylic Acids

Treatment of 4-(2-hydroaminoalkylidenyl)- and 4-(2-hydroxyalkylidenyl)-substituted isoxazol-5(4H)-ones with catalytic amounts of [RuCl2(p-cymene)]2, without any additive, afforded pyrazole- and isoxazole-4-carboxylic acids, respectively. The presence of an intramolecular H-bond in these substrates was the key to divert the classical mechanism toward a ring-opening non-decarboxylative path that is expected to generate a vinyl Ru-nitrenoid intermediate, the cyclization of which affords the rearranged products. A gram scale protocol demonstrated the synthetic applicability of this transformation.

Aryl-isoxazol-4-yl-imidazole derivatives

The present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula I: wherein R1 to R6 are as defmed in the specification and pharmaceutically acceptable acid addition salts thereof. This class of compounds h

ISOXAZOLECARBOXAMIDE DERIVATIVES

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