99299-02-2

Basic information

• Product Name: 3-Methyl-5-phenethyl-isoxazole-4-carboxylic acid
• CAS NO: 99299-02-2
• Molecular Weight: 231.251
• Mol File: 99299-02-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Methyl-5-phenethyl-isoxazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methyl-5-phenethyl-isoxazole-4-carboxylic acid(99299-02-2)
• EPA Substance Registry System: 3-Methyl-5-phenethyl-isoxazole-4-carboxylic acid(99299-02-2)

Safety Data

• Hazardous Substances Data: 99299-02-2(Hazardous Substances Data)

Upstream product

• 2510-36-3 3,5-dimethyl-4-isoxazolecarboxylic acid 
• 100-39-0 benzyl bromide 
• 106968-07-4 2-[1-Methylamino-eth-(Z)-ylidene]-3-oxo-5-phenyl-pentanoic acid ethyl ester 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 99299-05-5 (3-Methyl-5-phenethyl-isoxazol-4-yl)-methanol 

Relevant articles and documents

Metalation of Isoxazolyloxazolines, a Facile Route to Functionally Complex Isoxazoles: Utility, Scope, and Comparison to Dianion Methodology

2-(5'-Alkylisoxazol-4'-yl)-Δ2-oxazoline was metalated at the C-5' alkyl group, and the lithio anion was quenched with a variety of electrophiles.Alkyl halides, aldehydes, and acylpyridinium salts were used as electrophiles.The lithio anion was oxygenated with MOOPH or N-(phenylsulfonyl)oxaziridene.The isoxazolyloxazoline system was converted to the isoxazolyl carboxylic acid, aldehyde, ketone, and chiral oxazoline.The isoxazolyloxazoline was formed, metalated, and deprotected in synthetically useful yields and represents a facile entry into functionally complex isoxazoles.To determine the necessity of the oxazoline protection/deprotection scheme, dianions of isoxazole-4-carboxylic acids were studied.The dianion method was found to be more efficient for simple alkyl halides, but limited in scope.