99333-35-4

Basic information

• Product Name: Benzenamine, N-(1-ethoxy-2,2,2-trifluoroethyl)-4-methoxy-
• CAS NO: 99333-35-4
• Molecular Formula: C11H14F3NO2
• Molecular Weight: 249.233
• Mol File: 99333-35-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-(1-ethoxy-2,2,2-trifluoroethyl)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-(1-ethoxy-2,2,2-trifluoroethyl)-4-methoxy-(99333-35-4)
• EPA Substance Registry System: Benzenamine, N-(1-ethoxy-2,2,2-trifluoroethyl)-4-methoxy-(99333-35-4)

Safety Data

• Hazardous Substances Data: 99333-35-4(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 106-49-0 p-toluidine 

Downstream Products

• 282102-36-7 4,4,4-trifluoro-3-[(4-methoxyphenyl)amino]-1-phenylbutan-1-one 
• 771534-91-9 4,4,4-trifluoro-3-[(4-methoxyphenyl)amino]butanoic acid 
• 388077-33-6 ethyl 4,4,4-trifluoro-3-(N-4-methoxyphenyl)amino-2-carbethoxybutyrate 

Relevant articles and documents

One-Pot Synthesis of Functionalized β-Fluoroalkylated Mannich-Type Products from N-Aryl N,O-Acetals

A variety of functionalized β-amino-β-fluoroalkyl carbonyl compounds are accessible via a novel one-pot Mannich-type reaction of CF2- and CF3-containing N-aryl N,O-acetals with lithium enolates of ketones, esters, and nitriles. The resulting β-fluoroalkylated β-aminocarbonyl compounds are promising peptide surrogates to be used in drug development and for biological applications.

Nucleophilic reactions with α-trifluoromethyl imine and N,O-disubstituted aminal: Synthesis of β-trifluoromethyl β-anilino esters

The Reformatsky reaction with 4-methoxy-N-(2,2,2-trifluoroethylidene)aniline (1) proceeds under mild conditions to yield ethyl 4,4,4-trifluoro-3-(N-4-methoxyphenyl)amino-2-alkylbutyrate (5) and 4-trifluoromethyl-3-alkyl-1-(4-methoxyphenyl)-2-azetidinone (