282102-36-7Relevant academic research and scientific papers
Mannich-Type Reaction with Trifluoromethylated N,O-Hemiacetal: Facile Preparation of β-Amino-β-trifluoromethyl Carbonyl Compounds
Takaya, Jun,Kagoshima, Hirotaka,Akiyama, Takahiko
, p. 1577 - 1579 (2000)
(Matrix Presented) On treatment of silyl enolates and an N,O-hemiacetal, derived from trifluoroacetaldehyde ethyl hemiacetal and p-anisidine, with GaCl3 (0.2 equiv) and C6H5COCl (0.2 equiv) in propionitrile, Mannich-type r
One-Pot Synthesis of Functionalized β-Fluoroalkylated Mannich-Type Products from N-Aryl N,O-Acetals
Wunder, Swetlana,Deutsch, Amrei,Deutsch, Carl,Hoffmann-R?der, Anja
, p. 1167 - 1176 (2016/05/11)
A variety of functionalized β-amino-β-fluoroalkyl carbonyl compounds are accessible via a novel one-pot Mannich-type reaction of CF2- and CF3-containing N-aryl N,O-acetals with lithium enolates of ketones, esters, and nitriles. The resulting β-fluoroalkylated β-aminocarbonyl compounds are promising peptide surrogates to be used in drug development and for biological applications.
