99338-13-3

Upstream product

• 104-13-2 4-Butylaniline 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 99338-01-9 4'-n-butyl-4-[(dimethylaminosulfonyl)amino]benzanilide 
• 89092-37-5 4'-butyl-4-aminobenzanilide 

Relevant academic research and scientific papers

Sulfonamido-benzamide derivatives

Novel sulfonamide benzamides which have potent antiviral and anti-coccidial activities with low toxicity and compositions containing them used in prophylaxis or treatment of viral infectious diseases or coccidiosis are provided.

Synthesis and Antiviral Activity of Sulfonamidobenzophenone Oximes and Sulfonamidobenzamides

To find antiviral agents, various sulfonamidobenzophenone oximes (II) were synthesized from the appropriate m-sulfonamidobenzophenones by hydroxylamine reaction.The reaction products were generally obtained as syn/anti mixtures which were separable by fractional crystallization.The anti isomer had more potent antipoliovirus activity than the syn isomer.Various sulfonamidobenzamides (III) which were structurally related to II were synthesized by the reaction of amino-substituted benzamides with sulfuryl chloride or amines with (aminosulfonyl)benzoyl chloride.Antiviral activity was examined by the plaque-inhibition test.Compounds 5, 36, and 69 exhibited strong antipicornavirus activity.The structure-activity relationships are discussed.