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Usage

Uses

Used in Organic Synthesis and Medicinal Chemistry:
4-Bromooxindole is used as a building block in organic synthesis and medicinal chemistry for its potential biological activities and chemical reactivity. Its bromine atom makes it useful for various chemical reactions, contributing to the development of new drugs and the investigation of biological processes.
Used in Pharmaceutical Industry:
4-Bromooxindole is used as an antitumor and antimicrobial agent in the pharmaceutical industry. Its potential biological activities have been studied, making it a promising candidate for the development of new drugs targeting various diseases.
Used in Chemical Reactions:
The bromine atom in 4-bromooxindole makes it useful for various chemical reactions in organic chemistry. Its reactivity allows for the synthesis of new compounds and the modification of existing ones, expanding its applications in the field of chemistry.

InChI:InChI=1/C8H6BrNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11)

Upstream product

• 37777-74-5 2-(2-bromo-6-nitrophenyl)acetic acid 
• 603-83-8 3-nitro-o-tolylamine 
• 52488-36-5 4-bromo-1H-indole 
• 20780-72-7 4-bromoisatin 
• 1196150-98-7 tert-butyl 4-bromo-2-oxo-2,3-dihydro-1H-indole-1-carboxylate 
• 98592-11-1 6-bromo-2-nitrophenylpyruvic acid 
• 55289-35-5 2-bromo-6-nitrotoluene 

Downstream Products

• 400629-22-3 4-[4-(1-methyl-2-{[methylethylsulfonyl]amino}ethyl)phenyl]indolin-2-one 
• 1172589-06-8 (R)-tert-butyl 2-(2-oxoindolin-4-yl)pyrrolidine-1-carboxylate 
• 1172589-33-1 1‘-benzyl-4-bromo-1,2-dihydrospiro[indole-3,4’-piperidine]-2-one 
• 884855-68-9 4-bromo-1-methyl-1,3-dihydro-2-oxindole 
• 1374637-24-7 4'-bromo-2,6-diphenylspiro[cyclohexane-1,3'-indoline]-2',4-dione 
• 1637752-37-4 4'-bromospiro[cyclopropane-1,3'-indoline]-2'-one 
• 1150271-44-5 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 
• 1172588-54-3 1‘-benzyl-2-oxo-1,2-dihydrospiro[indole-3,4’-piperidine]-4-carbonitrile 
• 214759-51-0 4-cyano-1,3-dihydro-1H-indol-2-one 
• 885272-46-8 tert-butyl 4-bromo-2,3-dihydro-1H-indole-1-carboxylate 
• 86626-38-2 4-bromo-2,3-dihydro-1H-indole 

Relevant academic research and scientific papers

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocycl

NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

Provided are certain pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP

Selective reduction of carbonyl groups in the presence of low-valent titanium reagents

The chemoselective reduction of several structurally diverse compounds containing carbonyl groups was achieved in the presence of low-valent titanium reagents. This novel synthetic method provides easy access to highly selective reduction of carbonyl groups, and possesses several advantages including one-step procedure, convenient manipulation, good to excellent yields, and short reaction times.

Synthesis of the bicyclic welwitindolinone core via an alkylation/ cyclization cascade reaction

Synthesis of an advanced welwitindolinone intermediate via an alkylation/cyclization reaction is reported. The key step involves a one pot Lewis acid-mediated alkylation of a silylketene aminal with a furan alcohol followed by an intramolecular cyclizatio

TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS

The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula (I): or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula (I), including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula (I).

Heterocyclic sulfonamide derivatives

The present invention provides certain heterocyclic sulfonamide derivatives of formula (I): useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

Synthesis and some reactions of 6-bromooxindole

An efficient synthesis of 4- and 6-bromooxindoles, previously unknown compounds, from 6- and 4-amino-2-nitrotoluenes and the transformation of 6-bromooxindole to 3-acylated derivatives are described.