99365-60-3

Upstream product

• 1360876-62-5 N-methoxy-N-methyl-2-phenyl-2-(phenylamino)acetamide 
• 3761-92-0 n-hexylmagnesium bromide 
• 22065-57-2 ethyl 2-phenyldiazoacetate 
• 940866-95-5 ethyl N-phenyl-α-phenylglycinate 
• 62-53-3 aniline 
• 201230-82-2 carbon monoxide 
• 638-45-9 1-Iodohexane 
• 1750-36-3 (E)-N-benzylidenebenzenamine 

Downstream Products

• 1360998-09-9 4-hexyl-1,5-diphenyl-1H-imidazol-2-amine 

Relevant academic research and scientific papers

Ligand-Controlled Copper-Catalyzed Regiodivergent Carbonylative Synthesis of α-Amino Ketones and α-Boryl Amides from Imines and Alkyl Iodides

Regioselective transformation is among the long-standing challenges in organic synthesis. In this communication, a copper-catalyzed selectivity controlled regiodivergent borocarbonylation of imines with alkyl iodides has been developed. Various α-amino ketones and α-boryl amides were produced in moderate to good yields from the same substrates. The choice of the ligand is key for the regioselectivity control: α-amino ketones were produced selectively in good yields with (p-CF3C6H4)3P as the ligand, whereas the corresponding α-boryl amides were obtained with high regioselectivities when using MeIMes as the ligand.

Imidazole Derivatives Useful for Controlling Microbial Growth

Disclosure is provided for 1,4,5-substituted amino imidazole compounds useful to control microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same.

A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles

Diversified 1,4,5-substituted-2-aminoimidazoles were rapidly assembled via sequential N-H insertion and Grignard addition to α-diazoesters. Lead compounds were identified as antibiotics against Gram-positive bacteria with an MIC value as low as 2 μg/mL.