99367-57-4Relevant academic research and scientific papers
[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES
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Page/Page column 149-150, (2021/02/19)
The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS
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Paragraph 0668; 0674, (2018/06/12)
Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
Preparation of 1,3,4-Oxadiazol-2-carboxylic Acid Derivatives
Dost, J.,Heschel, M.,Stein, J.
, p. 109 - 116 (2007/10/02)
The synthesis of 5-substituted-1,3,4-oxadiazol-2-carboxylic acid derivatives 3a-g and 4a-g by cyclodehydratation of diacylhydrazines 1a-g and 2a-g are described.Further derivatives 6 to 9 are obtained from 1,3,4-oxadiazol-2-carboxethyl esters 3.
