99370-47-5

Upstream product

• 40786-69-4 1-(2,4-dihydroxy-3-propylphenyl)ethanone 
• 106-95-6 allyl bromide 

Downstream Products

• 140660-33-9 4-(4-cyanobutoxy)-5-allyl-2-hydroxy-3-propylacetophenone 
• 140660-26-0 4-(4-cyanobutoxy)-2-hydroxy-3,5-dipropylacetophenone 
• 99370-48-6 5-allyl-2,4-dihydroxy-3-propylacetophenone 

Relevant academic research and scientific papers

Leukotriene B4 Receptor Antagonists: The LY255283 Series of Hydroxyacetophenones

A series of hydroxyacetophenones was prepared for evaluation as leukotriene B4 (LTB4) receptor antagonists, culminating in 1-oxy>phenyl>ethanone (compound 35, LY255283).Using an assay for inhibition of specific LTB4 binding to human PMN, we found that substitution of a nonpolar substituent in the 5-position was required for activity.Best activity was realized with hydrogen in the 3-position, hydroxyl in the 2-position, short chain alkyl ketone in the 1-position, and a six- or eight-carbon chain linking the oxygen in the 4-position with an unsaturated terminal function.Compound 35, having an IC50 of 87 nM in the binding assay, was chosen for further preclinical evaluation.

Dioxo dibenzopyrans and anti-allergic use thereof

There are provided benzopyrans of formula I STR1 wherein R6 and R7 together form the chain --CHOCH=(A1 E1)--O-- in which --O-- is attached to R7, R5 represents hydrogen, R8 repre