99378-01-5

Upstream product

• 17617-05-9 pyridin-3-yl-methanethiol 
• 98376-23-9 (3S,4S)-4-(3-Bromo-2-oxo-propyl)-3-(1-fluoro-ethyl)-azetidin-2-one 
• 90497-22-6 [(2S,3S)-3-((S)-1-Fluoro-ethyl)-4-oxo-azetidin-2-yl]-acetic acid 
• 99377-93-2 [(2R,3R)-2-(3-Bromo-2-oxo-propyl)-3-((R)-1-fluoro-ethyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 99377-96-5 {(3R,4R)-3-((R)-1-Fluoro-ethyl)-2-oxo-4-[2-oxo-3-(pyridin-3-ylmethylsulfanyl)-propyl]-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 99377-92-1 [(2R,3R)-2-(2-Bromomethyl-[1,3]dioxolan-2-ylmethyl)-3-((R)-1-fluoro-ethyl)-4-oxo-azetidin-1-yl]-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-nitro-benzyl ester 
• 99377-91-0 (3S,4S)-4-(2-Bromomethyl-[1,3]dioxolan-2-ylmethyl)-3-((S)-1-fluoro-ethyl)-azetidin-2-one 
• 99377-97-6 (5R,6R)-6-((R)-1-Fluoro-ethyl)-7-oxo-3-(pyridin-3-ylmethylsulfanylmethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF CARBAPENEMS WITH A RXCH2-SUBSTITUENT IN THE 3-POSITION

Carbapenems 6 were prepared by reacting mercaptans with bromoketone 3 followed by a Wittig sequence, or better through advanced intermediate 9.The carbapenem carboxylates were chemically unstable; stability was not improved by changing the oxidation state