99391-22-7

Upstream product

• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 7559-36-6 4-methyl-β-nitrostyrene 
• 108-94-1 cyclohexanone 
• 101671-00-5 (E)-2-(4-methylphenyl)-1-nitroethene 
• 99391-19-2 u,l-4a,5,6,7,8,8a-hexahydro-4-(4-methylphenyl)-8a-<(trimethylsilyl)oxy>-4H-1,2-benzoxazine-2-oxide 
• 99391-19-2 l,l-4a,5,6,7,8,8a-hexahydro-4-(4-methylphenyl)-8a-<(trimethylsilyl)oxy>-4H-1,2-benzoxazine-2-oxide 

Downstream Products

• 1436787-48-2 (1R,2S,3R,4R,4aS,8aS)-8a-hydroxy-3-nitro-2-(4-nitrophenyl)-4-(p-tolyl)decahydronaphthalene-1-carbaldehyde 
• 1436787-40-4 (1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-3-nitro-2-(4-nitrophenyl)-4-(p-tolyl)decahydronaphthalene-1-carbaldehyde 
• 1436787-44-8 (2R,3R,4S,4aR)-3-nitro-2-(4-nitrophenyl)-4-(p-tolyl)-2,3,4,4a,5,6,7,8-octahydronaphthalene-1-carbaldehyde 
• 1436787-52-8 (2R,3S,4S,4aR)-3-nitro-2-(4-nitrophenyl)-4-(p-tolyl)-2,3,4,4a,5,6,7,8-octahydronaphthalene-1-carbaldehyde 
• 1288984-88-2 (1R,2S,3S,4R,4aS,8aS)-8a-hydroxy-3-nitro-2-phenyl-4-(p-tolyl)decahydronaphthalene-1-carbaldehyde 
• 1436787-01-7 (1R,2S,3R,4R,4aS,8aS)-8a-hydroxy-3-nitro-2-phenyl-4-(p-tolyl)decahydronaphthalene-1-carbaldehyde 
• 1436786-97-8 (2R,3R,4S,4aR)-3-nitro-2-phenyl-4-(p-tolyl)-2,3,4,4a,5,6,7,8-octahydronaphthalene-1-carbaldehyde 
• 1436787-05-1 (2R,3S,4S,4aR)-3-nitro-2-phenyl-4-(p-tolyl)-2,3,4,4a,5,6,7,8-octahydronaphthalene-1-carbaldehyde 

Relevant academic research and scientific papers

Achiral co-catalyst induced switches in catalytic asymmetric reactions on racemic mixtures (RRM): From stereodivergent RRM to stereoconvergent deracemization by combination of hydrogen bond donating and chiral amine catalysts

A stereochemical divergent approach for the highly enantioselective synthesis of distinct bicyclic products with multiple stereocenters from a racemate using a single chiral catalyst is disclosed. It is based on switches of the overall reaction pathways i

Acidic proteinase from Aspergillus usamii catalyzed Michael addition of ketones to nitroolefins

A new promiscuous activity of AUAP (acidic proteinase from Aspergillus usamii) was investigated in Michael addition of cyclic and acyclic ketones to aromatic and heteroaromatic nitroolefins in organic media in the presence of water. The yields were obtain

A novel mesoporous silica-grafted organocatalyst for the Michael addition reaction, synthesized via the click method

An efficient and recyclable mesoporous silica-grafted bifunctional acid-base organocatalyst for the Michael addition of ketones to β-nitrostyrenes has been synthesized by click chemistry, affording the products with excellent diastereoselectivity. A remar

Organocatalytic synthesis of multiple substituted b[4.4.0]decalin system

Chemical equations presented. An efficient and unprecedented organocatalytic reaction of γ-nitroketones with α,β-unsaturated aldehydes to give polyfunctionalized [4.4.0] bicyclic skeletons was developed. The diphenylprolinol silyl ether mediated nitro-Mic

C3-symmetric proline-functionalized organocatalysts: Enantioselective michael addition reactions

C3-Symmetric, tripodal catalyst 4 based on 1,3,5- triethylbenzene, which incorporates the features of a molecular receptor, is shown to catalyze Michael addition reactions ofcarbonyl compounds to β-nitrostyrenes in a high stereoselectivity (up to 99:1a dr and up to 98%ee). Copyright

Cyclic nitronates from the diastereoselective addition of 1-trimethylsilyloxycyclohexene to nitroolefins. Starting materials for stereoselective Henry reactions and 1,3-dipolar cycloadditions

Induced by a stoichiometric excess of dichloro(diisopropoxy)-titanium, 1-trimethylsilyloxycyclohexene and (E)-nitroolefins (R-CH=CHNO2, R = C6H5, p-C6H4CH3, p-C6H4OCH3, p-C6H4CN, CH3) combine in CH2Cl2 solution at -90 deg C preferentially with relative topicity ul, opposite to the corresponding reaction of enolates or enamines.The primary products are the epimeric bicyclic nitronates 4-6, which can be separated, and which are converted by KF in MeOH to the alkyl or aryl (nitroethyl)-substituted cyclohexanones 1 and 2 (Table 1).Instead of being solvolysed, the cyclic nitronates 4-6 can be used for nitroaldol additions to give the trisubstituted hexahydrobenzopyranols 15-19.Alternatively, 4-6 can be used in 1,3-dipolar cycloadditions with acrylates to furnish the tricyclic compounds 22-31.In either case, products with four asymmetric carbon atoms (not including acetal centres) are produced diastereoselectively.The addition described here is yet another example of an ul combination of trigonal centres induced by Lewis acids, overriding the influence of the configuration of the donor component.

Reversed Stereochemical Course of the Michael Addition of Cyclohexanone to β-nitrostyrenes by Using 1-(Trimethylsiloxy)cyclohexene/Dichloro(diisopropoxy)titanium

Induced by a stoichiometric excess of dichloro(diisopropoxy)titanium, 1-(trimethylsiloxy)cyclohexene and p-substituted β-nitrostyrenes (Y=H, CH3, CH3O, CN) combine in CH2Cl2 solution at -90 deg preferentially with relative topicity ul - opposite to the co