99406-01-6Relevant academic research and scientific papers
New Highlights in the Synthesis of 4-Aryl-1,4-dihydropyrazines
He, Jing-Yu,Song, Xiu-Qing,Yan, Hong,Zhong, Ru-Gang
, p. 1357 - 1361 (2012)
The 4-aryl-1,4-dihydropyrazines were prepared via the cyclization of N,N-bisalkylated anilines with ammonium acetate. These reactions were aided by improvements in the synthesis of N,N-bisalkylated anilines which were alkylated with anilines using ethyl 2-diazo acetoacetate in a reaction catalyzed by rhodium acetate in the absence of oxygen. A possible mechanistic route is postulated on the basis of the isolation of the N-alkylation intermediates, which were determined to be N-aryloxamates by 1H NMR data and X-ray diffraction.
