99414-69-4

Upstream product

• 90-15-3 α-naphthol 
• 711-79-5 1-hydroxy-2-acetonaphthone 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 1194587-67-1 4-methylene-3-(phenylamino)-3,4-dihydro-2H-naphtho[2,1-e][1,3]oxazin-2-one 
• 1194587-83-1 3'-phenyl-3-(phenylamino)-1',12'b-dihydro-12`b-methylspiro{4H-naphtho[2,1-e][1,3]oxazine-4,2'(3'H)-[5H]pyrazolo[1,5-c]naphtho[2,1-e][1,3]oxazine}-2,5'-dione 

Relevant academic research and scientific papers

Bioactive formylpyrazole analogues: Synthesis, antimicrobial, antioxidant and molecular docking studies

A series of six new 3-(1-hydroxynaphthalen-2-yl)-1-aryl-1 H-pyrazole-4-carbaldehyde derivatives were synthesized by Vilsmeier-Haack reaction of phenyl hydrazones. The new compounds were characterized by spectral studies and elemental analysis. Synthesized compounds were evaluated in vitro for their antimicrobial and antioxidant susceptibilities. The results suggest that the compounds with methyl and methoxy substitutions in the aromatic ring have good in vitro antimicrobial activities and those with methyl, methoxy and no substitutions possess promising DPPH and hydroxyl free radical scavenging abilities.

Cyclization of hydrazones of 2-acetyl-1-naphthol and 1-Acetyl-2-naphthol with triphosgene. Synthesis of spiro naphthoxazine dimers

Cyclization of hydrazones derived from 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with triphosgene gave naphtho[1,2-e]-1,3-oxazines, naphtho[2,1-e]-1,3-oxazines or their spiro dimers depending on the molar ratio of triphosgene used for the cyclization.

HYDRAZONE DERIVATIVES AND THEIR USE AS BETA SECRETASE INHIBITORS

The invention relates to compounds having the general formula (I) wherein R3 is selected from the group consisting of H, methyl and hydroxyalkyl, and wherein Z1 and Z2are selected independently from one another from the gr