99436-45-0

Upstream product

• 82449-88-5 (2S,3S)-2,3-o-isopropylidene-2,3-dihydroxy-1,4-(diphenylphosphinoxy)bitane 
• 32305-98-9 (+/-)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane 
• 32305-98-9 (-)-Diop 

Downstream Products

• 32305-98-9 (-)-Diop 
• 94665-49-3 (4R,5R)-4,5-Bis-(dicyclohexyl-phosphinoylmethyl)-2,2-dimethyl-[1,3]dioxolane 

Relevant academic research and scientific papers

Enantioselective chlorinative aldol reaction of α-substituted acroleins catalyzed by chiral phosphine oxides

The enantioselective chlorinative aldol reaction of α-substituted acroleins with aldehydes catalyzed by chiral phosphine oxides is described. A hypervalent silicon complex-derived chloride adds to the α-substituted acroleins to form the corresponding sily

Facile synthesis of chiral 1,2-chlorohydrins via the ring-opening of meso-epoxides catalyzed by chiral phosphine oxides

The facile synthesis of chiral 1,2-chlorohydrins via the enantioselective ring-opening of meso-epoxides with silicon tetrachloride in the presence of a chiral phosphine oxide was accomplished. The chiral 1,2-chlorohydrins were also obtained from the corresponding cis-alkenes in one-pot without significant loss in the selectivity, thereby permitting easy access to the 1,2-chlorohydrins from cis-alkenes with good yields and enantioselectivities.

Diastereo- and enantioselective reductive aldol reaction with trichlorosilane using Chiral Lewis bases as organocatalysts

Chiral Lewis base organocatalysts activate trichlorosilane to promote the tandem conjugate reduction/aldol reaction of α, β-unsaturated ketones with aldehydes to give optically active β-hydroxy ketones with good to high syn diastereo- and enantioselectivi

Catalyst for bisalkoxycarbonylation of olefins, and method for production of succinate derivatives

A catalyst for the bisalkoxycarbonylation of olefins comprising a noble metal compound and a phosphine chalcogenide of the following formula (1): wherein each of R1, R2 and R3 is, independently, an alkyl group or an aryl group each of which may have a substituent, and A is a Group 16 element of the Periodic Table; and R1, R2 or R3 may be combined, directly or through a bridging group, with one another where the groups to be combined may be attached either to an identical phosphorus atom or to different phosphorus atoms. Element A includes oxygen, sulfur and selenium atoms. The noble metal compound includes palladium(II) halides and other palladium compounds. The catalyst may further include a copper(I) halide or other copper compound as a co-catalyst. The use of this catalyst can provide the bisalkoxycarbonylation of olefins with efficiency.

The solution structures of chiral Ti(4+) alkoxides. II. The roles of diolate basicity and side-chain binding group polarity

With a view to reproduce the structures in solution of the Katsuki-Sharpless catalyst (the dimeric complex formed by homochiral diisopropyl tartrate with Ti(OiPr)4), five C2-symmetric chiral 2,3-butanediols, related to L-threitol but

SYNTHESE CHIRALER PHOSPHINOXIDE UND PHOSPHINE DURCH MICHAELIS-ARBUZOV-UMLAGERUNG

Several phosphinites and phosphites, derived from chiral alcohols, were synthesized.The phosphinites were subjected to a I2-catalyzed Michaelis-Arbuzov rearrangement.Phosphinites derived from primary alcohols give satisfactory yields of the corresponding phosphineoxides.Phosphinites synthesized from secondary alcohols also undergo the rearrangement but numerous byproducts appear in the reaction mixtures.Optical resolutions of chiral phosphineoxides by crystallization with optically active acids were not successful.The corresponding phosphines can easily be prepared by reduction of the oxides with trichlorosilane.

A SIMPLE CHIRAL SHIFT REAGENT FOR MEASUREMENT OF ENANTIOMERIC EXCESSES OF PHOSPHINE OXIDES

(R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylethylamine is a chiral shift reagent which allows ee measurements of various phosphine oxides.Good results were obtained for monophosphine oxides with asymmetric phosphorus centers as well as with an asymmetric carbon in α position of phosphorus.The reagent is also able differentiate the two enantiomers of racemic DIOP dioxide.

NEW ENTRY TO THE PREPARATION OF CHIRAL BIS(DICYCLOHEXYLPHOSPHINO)ALKANE DERIVATIVES. USE FOR RHODIUM-CATALYZED HYDROGENATION OF CARBONYL COMPOUNDS

Conversion has been achieved of two representative chiral diphosphines, (-)-DIOP and (S,S)-Chiraphos, into the corresponding bis(dicyclohexylphosphino)alkane derivatives, the latter being used for chiral ligands of the rhodium(I) catalyst in the homogeneous hydrogenation of prochiral carbonyl compounds.