99437-07-7

Upstream product

• 89020-11-1 dregeoside A₁₁ 
• 89020-12-2 dregeoside C₁₁ 
• 89020-10-0 dregeoside A₀₁ 
• 100776-60-1 Wilfoside W₃N 
• 100802-91-3 Wilfoside K₁N 
• 100776-61-2 Wilfoside W₁N 
• 100802-90-2 Wilfoside F₁N 
• 100776-59-8 Wilfoside G₁G 
• 117479-84-2 cynafoside-C 
• 89020-09-7 dregeoside A_p1 

Downstream Products

• 67968-33-6 methyl β-D-cymaropyranoside 
• 4166-79-4 methyl 2,6-dideoxy-3-O-methyl-α-D-ribo-hexopyranoside 
• 20561-89-1 D-cymaronic acid acid phenylhydrazide 
• 86972-07-8 Benzyl L-Oleandroside 
• 86972-07-8 benzyl 2-deoxy-3-O-methyl-α-L-rhamnopyranoside 
• 86972-08-9 Benzyl L-Oleandroside (α anomer) 
• 86972-10-3 Benzyl 4-O-Acetyl-L-oleandroside (α anomer) 
• 86972-09-0 Benzyl 4-O-Acetyl-L-oleandroside (β anomer) 
• 86972-09-0 Benzyl 4-O-Acetyl-L-oleandroside 
• 86972-13-6 Benzyl 2-O-<α-Ethoxy-α-(trifluoromethyl)phenylacetyl>-β-L-oleandroside 
• 123564-81-8 methyl β-L-diginopyranoside 3,5-dinitrophenylcarbamate 
• 123564-80-7 methyl α-L-diginopyranoside 3,5-dinitrophenylcarbamate 
• 105274-11-1 methyl β-D-cymarofuranoside 3,5-dinitrophenylcarbamate 
• 105274-10-0 methyl α-D-cymarofuranoside 3,5-dinitrophenylcarbamate 

Relevant academic research and scientific papers

Five new pregnane glycosides from Gymnema sylvestre and their α-glucosidase and &alphla;-amylase inhibitory activities

Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A-E (1-5) and four known oleanane saponins, 3β-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3β-O-β-D-xylopyranosyl-(1→6)-β-Dglucopyranosyl-(1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (8), and alternoside XIX (9). Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for their α-glucosidase and α-amylase inhibitory activities. Compounds 2-4 showed significant α-amylase inhibitory activity, with IC50 values ranging from 113.0 to 176.2 μM.

Structure determination of two new C21 steroidal glycosides from Cynanchum komarovii

Two new 13,14:14,15-disecopregnane-type C21 steroidal glycosides, namely komarosides R (1) and S (2), along with four known compounds (3–6), were obtained from the 95% ethanol extract of the whole herbs of Cynanchum komarovii Al.Iljinski (Asclepiadaceae). The structures of new compounds were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. Compounds 1 and 2 showed potent inhibitory activities against human leukemia cell line (HL-60) with IC50 values being 6.2 and 17.6?μM, respectively, compared to the positive control 5-fluorouracil (6.4?μM).

New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea

Phytochemical investigation on the stem of Ecdysanthera rosea led to the isolation of eight new C-21 pregnane glycoside ecdysosides A-H (1-8), together with one known pregnane glycoside ecdysantheroside A (9). Their structures were elucidated based on extensive spectroscopic data (MS, IR, 1D and 2D NMR) analysis, as well as comparison with the reported literature data. Antimicrobial activities of all the compounds were evaluated against bacteria and yeasts. Compounds 1, 9, 3 and 5 exhibited moderate antibacterial activities against respective Enterococcus faecalis and Providensia smartii, with MIC value of 12.5 μg/mL. Compound 8 showed significant anti-yeast activity against Cryptococcus neoformans with MIC value of 12.5 μg/mL.

Two new polyhydroxypregnane glycosides from the roots of Cynanchum otophyllum

Two new polyhydroxypregnane glycosides, namely cynotophyllosides I-J, were isolated from the roots of Cynanchum otophyllum, together with three known steroids, namely deacetylmetaplexigenin, sarcostin and hemoside. Their structures were established by ext

Cynanauriculoside C-E, three new antidepressant pregnane glycosides from Cynanchum auriculatum

Based on the bioactive screening results, three new pregnane glycosides named as cynanauriculoside C-E (1-3), were isolated from the roots of Cynanchum auriculatum Royle ex Wight (Asclepiadaceae), together with two known ones, otophylloside L (4) and cynauricuoside C (5). On the basis of detailed spectroscopic analysis and chemical method, the structures of new compounds were characterized to be qingyangshengenin 3-O-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranoside (1), qingyangshengenin 3-O-β-d-glucopyranosyl- (1 → 4)-β-d-glucopyranosyl-(1 → 4) -α-l-cymaropyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranoside (2) and caudatin 3-O-β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-digitoxopyranoside (3). In the despair mice models, these pregnane glycosides showed significant antidepressant activity at the dosage of 50 mg/kg (i.g.). The most potent one was cyanauriculatoisde D (2), which was close to the positive control fluoxetine (20 mg/kg).

New pregnane saponins from Ecdysanthera rosea and their cytotoxicity

Two new pregnane saponins elucidated as ecdysantheroside A (1) and ecdysantheroside B (2) and six known compounds (3-8) based on spectral data (MS, IR, 1D and 2D NMR) were isolated from the stem bark of Ecdysanthera rosea. The cytotoxicity against six cell lines of these compounds was tested by MTT assay. The results revealed that compounds 5 and 7 showed cytotoxicity against all the cell lines. Compound 2 showed cytotoxicity against cells A549, MDA435, HepG2, and HUVEC, while compound 4 showed cytotoxicity against cells A549, CEM, and HUVEC. Compound 6 had cytotoxicity against the others except cell HepG2.

Identification of new qingyangshengenin and caudatin glycosides from the roots of Cynanchum otophyllum

HPLC analysis of the roots of Cynanchum otophyllum Scheind (Asclepiadaceae) led to the isolation of six new pregnane glycosides, specifically otophyllosides N-P (2-4) and otophyllosides Q-S (7-9), in addition to the identification of three known C-21 steroidal glycosides, otophylloside A (1), otophylloside B (5) and caudatin 3-O-β-d-glucopyranosyl-(1→4)-β- d-oleandropyranosyl-(1→4)-β-d-cymaropyranosyl-(1→4) -β-d-cymaropyranoside (6). The structure of each glycoside was determined by detailed spectroscopic analysis and chemical methods. All compounds contain qingyangshengenin or caudatin aglycones and a straight sugar chain consisting of 4-7 hexosyl moieties with the mode of 1→4 linkage. The optically isomeric monosaccharides, d- and l-cymarose, coexisted in both otophyllosides R (8) and S (9).

Amurensiosides A-K, 11 new pregnane glycosides from the roots of Adonis amurensis

Five new pregnane tetraglycosides, amurensiosides A-E (1-5), two new pregnane hexaglycosides, amurensiosides F (6) and I (9), two new 18-norpregnane hexaglycosides, amurensiosides G (7) and H (8), and two new pregnane octaglycosides, amurensiosides J (10) and K (11), were isolated from the MeOH extract of the roots of Adonis amurensis. The structures of the new compounds were determined on the basis of extensive spectroscopic analysis, including two-dimensional (2D) NMR data, and the results of hydrolytic cleavage. The isolated compounds were evaluated for their cytotoxic activity against HSC-2 human oral squamous cell carcinoma cells.

Steroidal glycosides from the aerial part of Asclepias incarnata

The aerial part of Asclepias incarnata afforded 34 pregnane glycosides. These were confirmed to have lineolon, isolineolon, ikemagenin, 12-O- nicotinoyllineolon, deacylmetaplexigenin, metaplexigenin, rostratamine, 12-O- acetyllineolon, 15β-hydroxylineolon

THE PREGNANE GLYCOSIDE MARSDEKOISIDE A FROM MARSDENIA KOI

A new pregnane glycoside, mardekoiside A was isolated from the stems of Marsdenia koi (Asclepiadaceae) and its structure was elucidated from chemical and spectral data as 12-cinnamoyl-dihydrosarcostin-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1->4)-O-β-D-oleandropyranosyl-(1->4)-O-β-D-cymaropyranoside. Key words: Marsdenia koi; Asclepiadaceae; preganane glycoside; marsdekoiside A; structure elucidation.