99439-80-2Relevant academic research and scientific papers
Copper-catalyzed enantioselective conjugate addition of Grignard reagents to α,β-unsaturated esters
Lopez, Fernando,Harutyunyan, Syuzanna R.,Meetsma, Auke,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 2752 - 2756 (2007/10/03)
(Chemical Equation Presented) Stable dinuclear Cu complexes have been used to catalyze the conjugate addition of inexpensive and readily available Grignard reagents to acyclic α,β-unsaturated esters. The method provides the correspending β-substituted optically active esters in high yields and with excellent enantioselectivities (see scheme). R3 = cyclohexyl, R 4 = Ph or R3 = Ph, R4 = cyclohexyl.
Asymmetric Conjugate Addition of Organometallic Reagents to Chiral Vinyl Sulfoximines
Pyne, Stephen G.
, p. 81 - 87 (2007/10/02)
The chiral vinyl sulfoximines 1 and 2 (R' = C6H5, CH3, n-Bu, C6H5CH2CH2) have been prepared; they undergo conjugate addition reactions with organometallic reagents with high asymmetric induction.These conjugate addition adducts have been converted to chiral 3-alkylalkanoic acids in high enantiomeric excess (>90percent)
